Searchable abstracts of presentations at key conferences in endocrinology

ea0020p462 | Obesity and Metabolism | ECE2009

Impact of growth hormone receptor blockade on substrate metabolism during short-term fasting in healthy subjects

Moller Louise , Norrelund Helene , Frystyk Jan , Moller Niels , Jorgensen Jens OL

Context and objective: During fasting growth hormone (GH) promotes lipolysis, attenuates glucose oxidation and preserves protein. Previous studies have primarily been conducted in GH deficient patients or during somatostatin-suppression of GH secretion. We aimed to study the impact of the fasting associated increase in GH without concomitant changes in other hormones, by the means of GH receptor (GHR) blockade.Design: Ten healthy young men participated i...

ea0016p526 | Obesity | ECE2008

The effect of fasting on substrate metabolism and growth hormone signaling

Moller Louise , Dalman Lisa , Norrelund Helene , Billestrup Nils , Otto Jorgensen Jens

Background: Fasting is associated with suppression of IGF-I production, which is likely to be the stimulator of GH secretion and the subsequent increase in lipolysis. The GH signalling events subserving this switch in the actions of GH have not been studied.Aim: To assess whole body substrate metabolism and GH signalling proteins in skeletal muscle and fat in healthy human subjects in the postabsorptive state and after 38 h of fasting.<p class="abste...