Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep73 | Adrenal and Cardiovascular Endocrinology | ECE2022

A rare cause of Cushing’s syndrome

Favero Vittoria , Aresta Carmen , Parazzoli Chiara , Morelli Valentina , Chiodini Iacopo

Introduction: Aggressive ACTH-independent CushingÂ’s syndrome is rare and frequently related to malignant adrenocortical tumor. However, in exceptional situations, ectopic steroids secretion has been described.Case report: We report the case of an 87 years-old woman referred to our clinic in September 2020 after a low trauma sacral fracture. Her recent medical history revealed the onset, in the previous months, of severe hypokalemia, uncontrolled typ...

ea0081ep116 | Adrenal and Cardiovascular Endocrinology | ECE2022

Metyrapone treatment in bilateral macronodular adrenal hyperplasia: a report of two cases

Favero Vittoria , Aresta Carmen , Parazzoli Chiara , Chiodini Iacopo , Morelli Valentina

Introduction Primary bilateral macronodular adrenal hyperplasia (PBMAH) is potentially responsible for variable degree of cortisol excess. In patients with PBMAH the complete remission of cortisol hypersecretion can be achieved only by performing bilateral adrenalectomy, leading to a persistent hypocortisolism and to a consequent need of a lifelong glucocorticoid replacement therapy. Therefore, bilateral adrenalectomy is worth doing only in patients with severe hypercortisolis...

ea0081p6 | Adrenal and Cardiovascular Endocrinology | ECE2022

Primary aldosteronism and microprolactinoma: a new syndromic variant?

Parazzoli Chiara , Favero Vittoria , Morelli Valentina , Aresta Carmen , Chiodini Iacopo , Falchetti Alberto

Introduction: Primary aldosteronism (PA) has been described in association with endocrine and non-endocrine neoplasms. Aldosterone-producing adenomas mainly associate with hyperparathyroidism, prolactinomas and pancreatic endocrine tumors, particularly in the context of multiple endocrine neoplasia type 1 MEN1 syndrome. Next-generation sequencing (NGS) studies have shown frequent somatic mutations underlying PA and, rarely, germline mutations of CYP11B1/CYP11B2</e...

ea0081p277 | Adrenal and Cardiovascular Endocrinology | ECE2022

Presenting clinical features of Cushing’s syndrome and non-classic hypercortisolism

Delle Donne Elisa , Parazzoli Chiara , Favero Vittoria , Chiodini Iacopo , Morelli Valentina , Aresta Carmen

Background: The Endocrine Society Guidelines recommend screening for hypercortisolism especially in patients with specific features that best discriminate CushingÂ’s Syndrome (CS): easy bruising, facial plethora, proximal myopathy and striae. Clinical experience suggests that these features, though suggestive of hypercortisolism, are not enough sensitive. Indeed, patients with hypercortisolism frequently manifest primarily less discriminatory cortisol-related features, suc...

ea0037ep53 | Adrenal cortex | ECE2015

Beneficial effects of replacement therapy with modified-release hydrocortisone in patients with adrenal insufficiency

Morelli Valentina , Messina Erika , Mendola Marco , Cairoli Elisa , Ambrosi Bruno , Cannavo Salvatore , Chiodini Iacopo , Spada Anna

Introduction: The classical replacement therapy for hypoadrenalism may expose patients to non-physiologic glucocorticoids levels with negative metabolic consequences. Up to now, one study demonstrated that, as compared to the classical treatment, a modified-release hydrocortisone (MRH), improves weight, blood pressure, glycaemic control and QoL in a 3-month follow-up period. Few data are available on the long-term persistence of these benefits.Design/met...

ea0063gp95 | Adrenal and Neuroendocrine - Basic | ECE2019

The role of filamin A (FLNA) in the regulation of IGF2/IGF1R pathway in adrenocortical carcinomas

Peverelli Erika , Catalano Rosa , Giardino Elena , Mangili Federica , Treppiedi Donatella , Morelli Valentina , Mannelli Massimo , Spada Anna , Arosio Maura , Mantovani Giovanna

Adrenocortical carcinomas (ACCs) are rare endocrine tumors with poor prognosis. The insulin-like growth factor 2 (IGF2) is overexpressed in the great majority of ACC, and IGF2/IGF1R pathway acts as a proliferative autocrine loop, but to date IGF1R-targeted therapies have demonstrated a limited efficacy and the molecular mechanisms regulating this pathway are still unknown. The cytoskeleton acting-binding protein filamin A (FLNA), determinant in cancer progression and metastasi...

ea0070aep16 | Adrenal and Cardiovascular Endocrinology | ECE2020

Effects of adrenalectomy on arterial hypertension in patients with adrenal subclinical hypercortisolism: Preliminary results of a randomized clinical trial

Morelli Valentina , Frigerio Sofia , Aresta Carmen , Passeri Elena , Pugliese Flavia , Corbetta Sabrina , Scillitani Alfredo , Arosio Maura , Chiodini Iacopo

Introduction: The management of patients with adrenal incidentaloma (AI) and possible subclinical hypercortisolism (SH) is debated. This randomized study was aimed to evaluate the effects of adrenalectomy on arterial hypertension (AH).Methods: We consecutively evaluated 590 AI patients (referred to 3 Italian Centres between 06/2016 and 12/2019). Among these, 134 patients showed a possible SH (i.e. 1 mg DST between 1.8 and 5 µg/dl). Based on the excl...

ea0020p19 | Adrenal | ECE2009

Adipokine levels in patients with adrenal incidentaloma

Iorio Laura , Morelli Valentina , Coletti Francesca , Della Casa Sonia , Arosio Maura , Corsi Massimiliano , Chiodini Iacopo , Ambrosi Bruno

Patients (pts) with adrenal incidentaloma (AI) may show an increased incidence of several cardiovascular risk factors, as obesity, hypertension, diabetes mellitus and dyslipidemia. As previous data suggested that the increased cardiovascular risk in these pts could be in part mediated by alterations of adipokines, this study was aimed to evaluate plasma IL-6, resistin, CT-1 levels in a wide series of pts with AI.Ninety-three pts (42 males; 51 females; ag...

ea0016p16 | Adrenal | ECE2008

The role of midnight salivary cortisol levels in the diagnosis of subclinical hypercortisolism (SH) in patients with adrenal incidentaloma (AI)

Masserini Benedetta , Bergamaschi Silvia , Barbieri Annamaria , Salcuni Antonio , Morelli Valentina , Scillitani Alfredo , Beck-Peccoz Paolo , Chiodini Iacopo

Background: Several criteria (i.e., cortisol supprimibility after 1 mg overnight dexamethasone suppression test -F-dex-, low ACTH levels, high 24 h urinary free cortisol levels -UFC-, high midnight serum cortisol levels) have been used for defining SH. Nevertheless, a real gold standard combination of tests is lacking. Recently midnight salivary cortisol (MSC) has been described as a sensitive marker for the diagnosis of overt hypercortisolism, while the role of MSC in the dia...

ea0056p860 | Pituitary - Clinical | ECE2018

Mind the gap between cortisol levels measured with second generation assays and current diagnostic thresholds for the diagnosis of adrenal insufficiency: a single center experience

Grassi Giorgia , Morelli Valentina , Polledri Elisa , Fustinoni Silvia , Chiodini Iacopo , Ceriotti Ferruccio , D'Agostino Simona , Mantovani Giovanna , Arosio Maura

Objective: The current cut-offs to diagnose adrenal insufficiency (AI) have been established using outdated immunoassays. More modern methods have demonstrated less cross-reactivity with other steroids. The aim of our study was to evaluate the correlation between the cortisol assay Roche Cortisol I (R1), the newly available Roche Cortisol II (R2) and liquid chromatography tandem mass spectrometry (LC-MS/MS), the gold standard procedure for the measurement of steroids.<p cl...