Endocrine Abstracts

We present a case of 55 years old obese man with type 2 diabetes of 13 years duration, seen in diabetes clinic. His HbA1c had been 8–10% for about 7 years despite being on maximum doses of sulphonylurea and metformin.It was decided to start him on 30/70 mixed insulin and Metformin was continued. His HbA1c did not improve despite aggressive insulin titration. His injections became painful as insulin doses increased and resistance was noted on injecti...

This study investigated risk of cardiovascular (CV) events over a period of up to 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), compared with a historical control cohort of patients who did not receive rhPTH(1––84). The rhPTH(1–84)-treated patient cohort was derived from the NCT00732615 (REPLACE), NCT01...

This study evaluated risk of chronic kidney disease (CKD) outcomes over a period of up to 5 years in adult patients with chronic hypoparathyroidism treated with recombinant human parathyroid hormone (1–84), rhPTH(1–84), compared with a historical control cohort of patients who did not receive rhPTH(1–84). The cohort of patients with chronic hypoparathyroidism treated with rhPTH(1–84) was de...

Background: Prior small studies have suggested increased risk of infections in patients with hypoparathyroidism (HypoPT). This study using a large managed care cohort evaluated whether chronic HypoPT is associated with increased risk of sepsis, respiratory infections, and kidney or other genitourinary (GU) infections.Methods: A retrospective cohort study using a US commercial claims database (Q1 2007–Q2 2017) was conducted to examine the association...

Background: Previous studies of smaller size signaled heightened risk of CKD in patients with chronic HypoPT treated with conventional therapy (ie, oral calcium and active vitamin D). However, little is known about CKD progression, including progression to end-stage kidney disease (ESKD), in HypoPT patients.Methods: A retrospective cohort study, using a large US commercial claims database (Q1 2007–Q2 2017), was conducted to compare the risk of CKD b...

Background: Among chronic hypoparathyroidism (HypoPT) patients, the baseline prevalence of type 2 diabetes (T2D) appeared to be higher than the general population in previous studies. Since little is known about the potential assocation between HypoPT and T2D, this study evaluated whether HypoPT is associated with increased risk of T2D.Methods: A retrospective cohort study, based on a US commercial claims database (Q1 2007 – Q2 2017), was conducted ...

Background: Patients in end stage chronic kidney disease suffer from vascular calcification have high plasma level of phosphate (PO42−) and fibroblast grow factor 23 (FGF23). FGF23 is a ne...

Background: Prior small studies have suggested increased risk of cardiovascular (CV) conditions in patients with hypoparathyroidism (HypoPT). We evaluated whether chronic HypoPT is associated with increased risk of select CV hard endpoints (i.e., myocardial infarction (MI), stroke, and a composite CV endpoint) in a large contemporary cohort.Methods: A retrospective cohort study, based on a US commercial claims database (Q1 2007 - Q2 2017), was conducted ...

Introduction: The analysis of the signaling pathways involved in vascular calcification is difficult due largely to the limitation in obtaining vascular tissue samples. Therefore, the use of bioinformatics tools for the identification of potential biomarkers associated with vascular calcification is an advantage for the advancement in the knowledge of the molecular pathways involved in this pathology.Objective: Increase understanding of the molecular mec...

Introduction: Trabecular Bone Score (TBS) is a new non-invasive method to evaluate trabecular bone quality at the lumbar spine. The literature has contradictory results concerning the influence of insulin resistance and adipose tissue on bone, for this reason it is of interest to evaluate factors that determine bone health and risk of fracture in patients with T2DM.Objective: To analyze the relationship between insulin resistance and adipose tissue with ...