Searchable abstracts of presentations at key conferences in endocrinology

ea0075a12 | Adrenal gland | EYES2021

Evaluation of urinary free cortisol and late night salivary cortisol as diagnostic tools for Cushing’s Syndrome

Novizio Roberto , Locantore Pietro , Mura Chiara , Emanuele Rizzo Gaetano , Ramunno Vittoria , Maria Corsello Salvatore

Background: CushingÂ’s syndrome (CS) is characterized by inappropriate cortisol secretion and its diagnosis is still challenging for endocrinologist. Nevertheless, CS is a rare condition, making difficult to collect data and establish testsÂ’ diagnostic performances.Objectives: Assessing diagnostic performances of Urinary Free Cortisol (UFC) evaluated by liquid chromatography method coupled with tandem mass (LC-MS/MS) and Late Night Salivary Cort...

ea0075m03 | Metabolic Bone | EYES2021

Management of a rare life-threatening parathyroid carcinoma

Zelano Lorenzo , Maggio Ettore , Veleno Miriam , Mura Chiara , Morgante Cesare , Antonio Rota Carlo , Pontecorvi Alfredo

Background: Parathyroid carcinoma (PC) is rare, usually presenting with hyperparathyroidism and severe hypercalcemia. A standardized diagnostic, prognostic and therapeutic approach has not been provided yet and TNM staging algorithm is not universally accepted. Surgery is the first-choice treatment and is the only effective therapy to control hypercalcaemia. Chemo- or radio-therapy, local treatments or novel drugs should be reserved to selected cases.Cas...

ea0075t11 | Thyroid | EYES2021

Safety profile of Lenvatinib treatment in a mildly symptomatic Covid19 patient

Menotti Sara , Mura Chiara , Corsello Andrea , Ramunno Vittoria , Raia Salvatore , Maria Rosa , Pontecorvi Alfredo

Background: Lenvatinib is an oral chemotherapy for metastatic radioiodine-refractory differentiated thyroid cancer (RRDTC) which significantly improves progression free survival (PFS). It has been proved that higher rates of dose interruption or reduction of Lenvatinib have a negative impact on PFS. Patients with active cancer, such as RRDTC, have an increased risk of contracting Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and developing complications, especial...

ea0075t08 | Thyroid | EYES2021

Antibody Interference in Thyroid Assays: a case report

Mura Chiara , Menotti Sara , Zelano Lorenzo , Novizio Roberto , Rossi Laura , Carrozza Cinzia , Locantore Pietro , Maria Corsello Salvatore

Background: Endogenous and exogenous factors may cause biochemical interferences with thyroid function immunoassays. Interference can be caused by many mechanisms including heterophilic antibodies, drugs and rheumatoid factors. Moreover, assay-specific interference has been described, such as antithyroid hormone antibodies resulting in falsely elevated or lowered concentrations depending on the assay.Case Presentation: We describe a case of a 38-years ol...