Searchable abstracts of presentations at key conferences in endocrinology

ea0062p72 | Poster Presentations | EU2019

Challenges in managing a young lady with recurrent unexplained hypoglycaemia

Robbins Tim , Murthy Narasimha , Gholap Nitin

Case history: A 23-year-old Caucasian nurse presented with six months of frequent recurrent symptomatic hypoglycaemic episodes with capillary blood glucose ranging between 1.2 and 3.5 mmol/l and symptoms improving after a carbohydrate snack or a drink. The episodes were more likely to occur during fasting state and after excess physical activities. A careful history excluded intake of any off-prescription medications, dfrugs or psychosocial problem.Inves...

ea0034p11 | Bone | SFEBES2014

Unusual cause of hypocalcemia

Pelluri Lavanya , Hariman Christian , Murthy Narasimha

Introduction: We present a rare cause of hypoparathyroidism and hypocalcemia and implications of the same during pregnancy.Case report: A 22-year-old primigravida was referred to the antenatal endocrine clinic with a longstanding history of hypoparathyroidism with hypocalcaemia. She had short stature and extended digits relative to her height. She has been taking alfacalcidol 0.5 μg once a day and adcal D3 tablets and blood tests revealed low normal...

ea0065p66 | Adrenal and Cardiovascular | SFEBES2019

Waterhouse–Friderichsen syndrome: an endocrine emergency

Gatdula Erneda Reyes , Cho Sanda , Rao Ranganatha , Murthy Narasimha

Waterhouse–Friderichsen Syndrome is adrenal gland failure due to adrenal haemorrhage. It is an uncommon but usually life-threatening condition, which can be one of the serious complications of severe sepsis. Clinical manifestations of adrenal haemorrhage can vary widely depending on the degree and rate of haemorrhage. Adrenal haemorrhage may result from trauma, sepsis, anticoagulation medication, coagulopathy, autoimmune conditions, underlying tumour or idiopathic disease...

ea0028p2 | Bone | SFEBES2012

A case of HPT-JT syndrome with mutation involving exon 2 of CDC73 gene

Rao Ranganatha , Sivaraman Subash , Harrold Christopher , Murthy Narasimha , Sankar Sailesh

Background: Primary Hyperparathyroidism - Jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterised by hyperparathyroidism and ossifying jaw fibromas. Inactivating germline mutations in CDC73 gene (previously known as HRPT2) is the main cause of this syndrome. There is higher incidence of parathyroid carcinoma in these individuals and also an association with other renal lesions have been described. We report a case of HPT-JT syndrome with mutation in the ex...

ea0077p200 | Metabolism, Obesity and Diabetes | SFEBES2021

Management of the common within the uncommon: Euglycemic ketoacidosis in Bloom’s syndrome

Nair Nalini , Awala Orighomisan , Thadani Puja , Yasear Zhainab , Rao Ranganatha , Murthy Narasimha , Sankar Sailesh , Randeeva Harpal

Background: Bloom’s syndrome is a rare autosomal recessive disorder due to chromosomal instability. It is associated with endocrinopathies such as growth deficiency, insulin resistance, type 2 diabetes, dyslipidemia and hypothyroidism. We present a case to highlight the challenges in management of diabetic emergencies in patients with complex syndromes.Case report: A 38-year-old male of Asian descent known to have Bloom’s syndrome presented to ...

ea0086p34 | Bone and Calcium | SFEBES2022

Important learning lessons from a rare case of hypoparathyroidism

Leonidas Liarakos Alexandros , Tran Patrick , Page Tristan , Rao Ranganatha , Murthy Narasimha

Background: Genetic causes of hypocalcaemia can be overlooked in patients presenting without apparent syndromic features. One such example is DiGeorge syndrome, which is often diagnosed in childhood but rarely in adulthood.Case presentation: A 21-year-old lady was referred to our endocrinology clinic regarding chronic hypocalcaemia (adjusted calcium 1.98 mmol/l). This was first diagnosed at the age of eight with no clear cause identified. Her past medica...

ea0086p260 | Neuroendocrinology and Pituitary | SFEBES2022

Cushing’s Syndrome – A medical emergency and diagnostic challenge

Thadani Puja , Chaudhury Nadia , Murthy Narasimha , Rao Ranganatha , Randeva Harpal , Weickert Martin , Gholap Nitin

Background: Ectopic Cushing’s syndrome (ECS) is a rare and severe condition at times presenting acutely with intense hypercortisolism. The intensity of hypercortisolism can be disproportionate to underlying tumoral condition, and associated life-threatening complications are common arising suddenly. Hypercortisolism must be controlled rapidly pending definitive treatment of tumoral source to avoid life-threatening consequences.Case Summary: 31-year-...

ea0028p100 | Clinical practice/governance and case reports | SFEBES2012

A case of unrecognized maternal PTH resistance and severe impact on neonatal bone mineralisation

Sivaraman Subash , Rao Ranganath , Murthy Narasimha , Weickhert Mi , Randeva Hs , Sankaranarayanan Sailesh , Harrold Christopher

A 25 year old lady was referred to the endocrine clinic after her newborn baby was noted to have respiratory problems, marked osteopenia and hypocalcemia. Further investigations on the mother showed corrected calcium of 1.11 mmol/L; however she was relatively asymptomatic. Reviewing her history in detail, she was born in Nigeria and moved to the UK 2 years prior to the presentation. She used to get intermittent cramps in her hands, legs and body since the age of 10 in addition...

ea0015p34 | Clinical practice/governance and case reports | SFEBES2008

Thyrotoxicosis management audit

Kumar Anupa , Murthy Narasimha PN , Anwar Aresh , Randheva Harpal , Bellary Shrikanth , Sankar Sailesh

Introduction: Thyrotoxicosis is one of the common referrals to the endocrine clinic. Management of the thyrotoxicosis depends on establishing the correct aetiology. The aim of the audit was to compare the management of patients with thyrotoxicosis against the guidelines proposed by the Royal College of Physicians.Methods: One hundred and two consecutive patients referred to outpatient endocrine unit in a University Hospital over 6 months were included. D...

ea0075m12 | Metabolic Bone | EYES2021

Management considerations for adults with x-linked hypophosphatemia: A case report

Thadani Puja , Khan Uzma , Murthy Narasimha , Rao Ranganatha , Sankar Sailesh , Randeva Harpal

Background: X-linked hypophosphatemia (XLH) is a rare, hereditary, progressive musculoskeletal disorder. Prompt diagnosis and treatment in childhood ensures adequate bone matrix mineralization and skeletal growth. There is no consensus on indications for treatment in adult patients.Case Presentation: A 25 year old female was referred to endocrinology with a right ankle fragility fracture. She was known to have XLH, diagnosed in Poland at the age of 1 yea...