Searchable abstracts of presentations at key conferences in endocrinology

ea0033cme2 | CME TRAINING DAY | BSPED2013

Vitamin D and rickets

Shaw N

Rickets is a condition only seen in growing children due to disorders that result in impaired apoptosis of hypertrophic cells and mineralisation of the growth plate and osteoid. Although there are a variety of causes of rickets vitamin D deficiency remains the commonest cause worldwide with evidence of a resurgence in some developed countries.There are several modes of presentation of vitamin D deficiency dependent on the age and growth rate of the child...

ea0033cme3 | CME TRAINING DAY | BSPED2013

Osteoporosis in children and young people

Bishop N

What do we mean by ‘osteoporosis’? Essentially, bone of reduced mass that is abnormal at a micro-architectural level, with an increased propensity to fracture. The detection of such abnormality is not straight-forward. Any bone will fracture given sufficient force, and it might be thought that restricting further investigation to those who fracture following mild or trivial trauma would be the way forward. Defining what level of trauma should be regarded as ‘mil...

ea0029s25.3 | Reproductive hormone action | ICEECE2012

Extragonadal FSH action- facts and dreams

Ghinea N.

Early detection is essential for curative cancer therapy and for achieving a decrease in cancer mortality. Markers for incipient stages of every type of cancer constitute therefore all oncologists’ dream. We have recently uncovered a new tumor marker, the FSH receptor (FSHR). Compared with the available markers, FSHR is found in a wide array of cancers, including eleven of the most frequent types. We have shown by various methods that FSHR is expressed in >1300 human ...

ea0029s57.1 | What's new in congenital adrenal hyperplasia (CAH)? | ICEECE2012

Congenital adrenal hyperplasia: counselling from birth to the next generation

Krone N.

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders causing deficient cortisol synthesis. The commonest cause, 21-hydroxylase deficiency, accounts for about 90–95% of cases. Other entities such as deficiencies of 11β-hydroxylase, 17α-hydroxylase, 3β-hydroxysteroid dehydrogenase type 2, and P450 oxidoreductase are considerably rarer. The differential diagnosis has to be established as different forms of CAH will require different...

ea0029mte16 | (1) | ICEECE2012

Management of non-functioning pituitary adenomas

Karavitaki N.

Non-functioning pituitary adenomas (NFAs) are benign pituitary neoplasms arising from the adenohypophyseal cells. They are not associated with clinical evidence of hormonal hypersecretion and have a prevalence of 22 cases per 100,000 people. At presentation, the majority is macroadenomas and their clinical manifestations are the result of pressure effects to surrounding structures.Management options include observation, surgical removal combined or not w...

ea0012s33 | Adipocyte tissue and insulin resistance | SFE2006

What role for adipocytokines in insulin resistance and diabetes prediction? From genes to epidemiology

Sattar N

Excess weight/obesity is a major risk factor for type 2 diabetes. Mechanisms linking obesity to insulin resistance in other liver and skeletal muscle are of considerable interest and the role of adipokines, in particular adiponectin, has come under considerable interest. Adiponectin is exclusively produced by fat cells but its circulating levels are paradoxically reduced in obesity. Current weight of evidence from prospective studies suggest that high adiponectin levels are pr...

ea0011s100 | Metabolic syndrome | ECE2006

Metabolic syndrome

Finer N

Bjorntorp first coined the term ‘metabolic syndrome’ (MS) in the 1980’s to describe the association between obesity, regional fat distribution, disease endpoints and their risk factors (cardiovascular disease, premature death, stroke, non-insulin-dependent diabetes mellitus and female carcinomas). This description also recognised the potential contribution from adreno-cortical activity and stress. Since that time a plethora of research has highlighted the causat...

ea0010s8 | Non classical sites of action of classical hormones | SFE2005

The sodium/iodide symporter (NIS): recent frontiers

Carrasco N

The Na+/I- symporter (NIS) is an intrinsic plasma membrane glycoprotein that mediates active I- transport in the thyroid follicular cells, the first step in thyroid hormone biosynthesis. Na+/I- symport occurs with a two Na+ per one I- stoichiometry. Endogenous functional expression of NIS in thyroid cancer is the foundation for the single most effective and most side effect-free anti-cancerous targete...