Endocrine Abstracts

A 29 year old lady with a past history of seronegative rheumatoid arthritis, Vitamin B12 deficiency, autoimmune hypothyroidism and fibromyalgia who had feeling unwell with a left sided headache for a few days had a fall at home witnessed by her friend. She was noted to be in peri arrest state by ambulance crew on their arrival. Agonal breathing was noted and monitor revealed VF. She was given 5 DC shocks with return of spontaneous circulation and regained consciousness. She wa...

Background: Thyroid nodule is the most common endocrine disorder with the prevalence of more than 50% in adults. Majority of nodules are small in size and can be detected only by various imaging methods. Thyroid nodules are usually benign, asymptomatic, and do not need treatment. Growing and large symptomatic thyroid nodules are usually treated with thyroidectomy. Novel minimally invasive ablation techniques can be alternative to surgery. Percutaneous laser ablation is causing...

Introduction: The prevalence of thyroid nodules detected by ultrasound (US) is up to 50% in general population and approximately 5−10% of them is malignant. Diagnostic assessment includes laboratory tests thyroid US and thyroid scintigraphy, where suspicious nodules are characteristically cold when using99m Tc-pertechnetate as a tracer. A useful tool for US-based risk stratification of thyroid nodules is Thyroid Imaging Reporting and Data System (TIRADS). Rece...

Objectives: Ultrasound-guided fine needle aspiration biopsy (FNAB) is a commonly performed diagnostic procedure for evaluation of thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology comprises six categories. Bethesda categories I and III present a challenge for deciding on further diagnostic and therapeutic procedures. Category I includes non-diagnostic or unsatisfactory results that may be due to both aspiration of cystic material from simple cysts or asp...

Background: Solitary fibrous tumor of pleura represents a prototypical mesenchymal neoplasm that induces non-islet cell tumor hypoglycemia due to overproduction of insulin-like growth factor 2, named Dodge Potter syndrome.Case Presentation: An 86-year-old man, non-diabetic, was admitted to hospital with a few months history of repetitive hypoglycemic symptoms and documented low blood glucose of 1.9 and 1.2 mmol/L on two occasions when he lost consciousne...

Thyroid C-cells, as a second type of endocrine cell population within thyroid, produce and secrete peptide hormone calcitonin (CT). This hypocalcemic hormone acts as an inhibitor of bone resorption. The aging is a complex process that alters various cellular functions. Therefore, the aim of this study was to examine the aging-related changes in the structure and function of CT-producing thyroid C-cells in male Wistar rats, using histomorphometric, ultrastructural and biochemic...

Calcitonin (CT) is a hypocalcemic hormone produced by thyroid C-cells that acts as an bone antiresorptive agent. The other endocrine cell population in thyroid, called follicular cells produce thyroid hormones (TH) which also affect bone turnover. In this study, we evaluated the effects of salmon CT administration on structure and function of both CT and TH producing thyroid cells as well as trabecular bone microarchitecture in orchidectomized (Orx) middle-aged rats. Fifteen-m...