Endocrine Abstracts

Introduction: Aldosterone synthase participates in the key reactions of aldosterone synthesis – 11-hydroxylation, 18-hydroxylation and, finally, 18-oxidation. In recent works devoted to evaluating the effectiveness of hybrid steroids in the differential diagnosis of subtypes of primary aldosteronism (PA), it is worth emphasizing the experience of using high-performance liquid chromatography – tandem mass spectrometry (HPLC-MS/MS), which allows detecting even very low...

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...

CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. In addition, CY...

Introduction: This problem has a major social and medical significance. The prevalence of secondary endocrine hypertension is around 40%, of which primary aldosteronism is up to 15% and is usually developed at working age. Despite of improvement of diagnostical two-step method of finding primary aldosteronism, none of these test results can be considered reliable because of false positive and false negative results. That’s why the problem of endocrine hypertension diagnos...

Relevance: Due to numerous causes of PA, AVS allows differentiating variant nosological forms of PA. The importance of differential diagnosis is due to the fact that surgery is reasonable only with unilateral variant of PA, while in idiopathic hyperaldosteronism surgery isn’t a method of choice.Purpose: To assess the diagnostic possibilities of using AVS against the background of endogenous stimulation of adrenocorticotropic hormone (ACTH) in the ea...