Endocrine Abstracts

Background: Bone marrow fat is a unique fat depot that is regulated independently of other fat depots. Estradiol is an important regulator of bone marrow fat. This is illustrated by an increase in marrow fat fraction after menopause and a decrease following estradiol replacement. We hypothesize that estradiol is the major sex steroid that regulates bone marrow fat not only in women, but also in men.Methods: This is an open-label partly randomized interve...

Objective: Visceral adipose tissue (VAT) and liver fat content are associated with insulin resistance and cardiovascular disease and show clear sex differences. Our objective is to determine the effect of estradiol and testosterone on VAT and liver fat content in trans women (assigned male at birth, identify as female) and trans men (assigned female at birth, identify as male).Design: Open-label partly randomized intervention study in 8 trans women and 1...