Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp186 | Reproduction & Endocrine Disruption | ECE2016

FSH increases the different LH- and hCG-dependent intracellular signalling and the downstream life/death signals in vitro

Casarini Livio , Riccetti Laura , De Pascali Francesco , Nicoli Alessia , Tagliavini Simonetta , Trenti Tommaso , Battista La Sala Giovanni , Simoni Manuela

Background: Luteinizing hormone (LH) and choriogonadotropin (hCG) are glycoprotein hormones regulating ovarian function and pregnancy. They were routinely used in assisted reproduction techniques (ART) assuming they are equivalent, due to their binding to a common receptor (LHCGR). However, differences between LH and hCG were demonstrated at molecular and physiological level.Aim: The aim of this study is to evaluate how follicle-stimulating hormone (FSH)...

ea0049ep1123 | Female Reproduction | ECE2017

Heterogeneous hCG and hMG commercial preparations result in biased intracellular signaling but induce similar progesterone response in vitro

Riccetti Laura , Klett Daniele , Ayoub Mohammed Akli , Boulo Thomas , Mariot Julie , Pignatti Elisa , Tagliavini Simonetta , Varani Manuela , Tranti Tommaso , Nicoli Alessia , Sala Giovanni Battista La , Combarnous Yves , Reiter Eric , Simoni Manuela , Casarini Livio

Human chorionic gonadotropin (hCG) is the pregnancy hormone marketed as a drug for assisted reproduction technologies to support follicle-stimulating hormone action. Several hCG formulations are commercially available, differing in source, purification methods and biochemical composition. In this study, we investigated the molecular features and the intracellular signaling mediated by five urinary and recombinant hCGs. The drug comparisons were performed by quantifying the hor...