Searchable abstracts of presentations at key conferences in endocrinology

ea0063d3.1 | T4 is not enough | ECE2019

‘Yes, T4 is not enough’

Nygaard Birte

Most L-T4 treated hypothyroid patients return to normal health without complaints. However, persistent symptoms such as tiredness, depression, decreased cognitive function, weight increase and musculoskeletal symptoms are described in 25% of L-T4 treated hypothyroid patients compared to 15–20% in controls. It has been assumed that all the necessary T3 could be derived from peripheral de-iodination of orally administered L-T4. Nevertheless, data has pointed towards a possi...

ea0092ps3-21-07 | Hypothyroidism | ETA2023

Assessing the risk of atrial fibrillation in hypothyroid women prescribed with liothyronine: A retrospective cohort study

La Cour Jeppe , Kristensen Soren , Nygaard Birte , Selmer Christian

Background: Whether combination therapy of levothyroxine and liothyronine increases the risk of atrial fibrillation remains a topic of debate.Objectives: The objective of this study was to investigate the risk of atrial fibrillation in individuals with hypothyroidism treated with a combination of levothyroxine and liothyronine.Methods: We conducted a retrospective cohort study using individual-level linkage of Danish nationwide reg...

ea0035oc1.3 | Thyroid clinical | ECE2014

Chronic liothyronine (T3) treatment in stable heart failure patients with low T3 syndrome: A randomised, double-blind, cross-over, placebo-controlled intervention study (The LIHFA study)

Holmager Pernille , Schmidt Ulla , Dall Mark Peter , Dominguez Helena , Zerahn Bo , Raymond Ilan , Kistorp Caroline , Nygaard Birte , Faber Jens

Background and aim: Low T3 syndrome is associated with a poor prognosis in patients with chronic heart failure (CHF). It is controversial whether T3 treatment is indicated in CHF. A previous study using intravenous infusion of T3 for 72 h suggested a beneficial effect on cardiac performance.We aimed to evaluate the effect of 13 weeks of T3 treatment in patients with stable CHF on left ventricular ejection fraction (LVEF) compared to placebo.<p class=...

ea0092op-04-01 | Oral Session 4: Young Investigators / Clinical and Translational | ETA2023

Interaction between DIO2 polymorphisms and LT4 treatment on psychological well-being outcomes and cardiovascular risk factors: a population-based cross-sectional study in uk biobank

Zinck Jensen Christian , Lynggaard Isaksen Jonas , Ahlberg Gustav , Salling Olesen Morten , Nygaard Birte , Ellervik Christina , Kim Kanters Jorgen

Objectives: Some evidence suggests gene-treatment interactions might cause persistent symptoms in individuals receiving levothyroxine (LT4) treatment. We investigated, as previously hypothesized, if single nucleotide polymorphisms (SNPs) in rs225014 (Thr92Ala), rs225015, or rs12885300 (ORFa-Gly3Asp) in the Deiodinase 2 gene (DIO2), or rs17606253 in the Monocarboxylate Transporter 10 gene (MCT10) were associated with outcomes indicative of local tissue hypothyroidism in LT4-tre...

ea0056p1082 | Thyroid (non-cancer) | ECE2018

How should thyroid-related quality of life be assessed? Standard recall measures compared with here-and-now measures

Boesen Victor Brun , Feldt-Rasmussen Ulla , Bjorner Jakob Bue , Cramon Per , Gronvold Mogens , Nygaard Birte , Rasmussen AEse Krogh , Vilsboll Tina , Watt Torquil

Introduction: Some methodologists have raised concern about the validity of the standard method of assessing patient-reported outcomes, i.e. retrospective questionnaires. Repeated momentary measurements have been introduced to avoid recall bias and provide ecological validity. Although having theoretical advantages, the measurement properties remain unsubstantiated. This study examines the relationship between the retrospective thyroid-related quality of life patient-reported ...

ea0084ps2-06-53 | Hypothyroidism Treatment | ETA2022

Whole-body oxidative stress measured by biomarkers of RNA and DNA damage is higher in hypothyroid women, even after treatment, than in healthy individuals, measured by biomarkers of RNA and DNA damage

R. Riis Kamilla , B. Larsen Camilla , R. Medici Bjarke , Jensen Christian Z. , H. Winter Kristian , L. Larsen Emil , Bronden Andreas , Ellervik Christina , L. la Cour Jeppe , Hegedus Laszlo , H. Brix Thomas , E. Poulsen Henrik , Faber Jens , K. Knop Filip , Nygaard Birte , J. Bonnema Steen

Introduction: Hypothyroidism has been associated with oxidative stress. Urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG), respectively, represent whole-body RNA and DNA oxidation. While these biomarkers have been associated with increased morbidity and mortality in various diseases, they have been only sparsely explored in patients with thyroid disorders.Method: In 45 women with newly diagn...