Searchable abstracts of presentations at key conferences in endocrinology

ea0032p993 | Thyroid (non-cancer) | ECE2013

Levothyroxine requirements in thyroidectomized diabetic patients receiving metformin

Zafon Carles , Casteras Anna , Obiols Gabriel , Mesa Jordi

Background: Recent studies suggest that metformin (MF) may reduce TSH concentration. This fact could imply a dosage reduction of levothyroxine among those hypothyroid patients taking metformin.Aim: To determine, in a retrospective analysis, the impact of metformin in thyroidectomized patients (a condition not influenced by endogenous thyroid hormone production) on levothyroxine replacement.Patients and methods: One hundred ninety t...

ea0022p798 | Thyroid | ECE2010

Usefulness of sorafenib in the management of advanced thyroid carcinoma

Obiols Gabriel , Capdevila Jaume , Zafon Carles , Mesa Jordi

One of the most important activating genetic aberrations in differentiated thyroid cancer (DTC) development pathways involves the RET/PTC–RAS–RAF–MAPK axis. Mutations in the RET gene are essential in medullary thyroid carcinoma (MTC). Sorafenib is the first compound to reach clinical practice that is capable of inhibiting all the RAF kinases. Moreover, it targets a panel of tyrosine kinase receptors, such as VEGF receptors which gives to sorafenib not only proap...

ea0037ep872 | Thyroid cancer | ECE2015

Role of thyroglobulin as a predictor of the evolution of disease in differentiated thyroid cancer

Biagetti Betina , Zafon Carles , Garcia-Burillo Amparo , Velasco Monica , Obiols Gabriel , Castell Joan , Mesa Jordi

Aim: Investigate, in patients with differentiated thyroid cancer (DTC) if thyroglobulin (Tg) values, immediately before and six months post radioiodine ablation are good predictors of disease progression.Materials and methods: Basal Tg values (Tg-B) and rhTSH stimulated Tg (Tg-S) before ablation (0) and 6 months later (6) from 142 DTC patients, with post-surgical ablation therapy between 2003 and 2009 with a follow up of 5 years, were analysed.<p cla...

ea0037ep905 | Thyroid cancer | ECE2015

Efficacy and safety of an outpatient low radioide dose for remnant thyroid ablation in low risk papillary thyroid carcinoma (PTC)

Obiols Gabriel , Garcia-Burillo Amparo , Zafon Carles , Castell Joan , Mesa Jordi

In PTC, radioiodine required dose for thyroid remnant ablation is uncertain. Recent works show that low doses may be sufficient for low risk patients.Aim: To evaluate the efficacy and safety of thyroid remnant ablation in patients with low-risk PTC by using 1100 MBq (30 mCi) outpatient doses.Materials and methods: Twenty-five patients (24 women, 55 years-old mean age, range 34–77) referred for ablation of postsurgical thyroid ...

ea0032p937 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Carbohydrate metabolism in acromegaly and treatment impact

Biagetti Betina , Valladares Silvia , Arnez Lorena , Dalama Belen , Obiols Gabriel , Mesa Jordi

Introduction: Generously supported by IPSEN)-->Carbohydrate metabolism (CHM) is impaired in over 30% of acromegalic patients. Natural history of acromegaly and treatment modalities, i.e. surgery, somatostatin analogues (SSA) and pegvisomant, may impact in a different way on CHM.Aim: To assess CHM alterations (impaired fasting glucose (IFG) and diabetes mellitus (DM)) in acromegaly and their relationship with cl...

ea0022p778 | Thyroid | ECE2010

Clinical and histological different features in the form of presentation between papillary microcarcinomas and papillary carcinomas of larger size

Zafon Carles , Fort Jose Manuel , Baena Juan Antonio , Castellvi Josep , Obiols Gabriel , Monroy Gabriela , Mesa Jordi

Background and aim: Papillary thyroid carcinomas (PTCs) with a diameter <1 cm are referred to as papillary microcarcinomas (PTMCs). They are being diagnosed with increasing frequency. Within this type of tumour some clinical and histological characteristics with prognostic and therapeutic impact have been proposed. In the present study we describe the clinical and pathological presentation of PTMCs and compare them with papillary thyroid carcinomas of larger size.<p cl...

ea0041gp223 | Thyroid Cancer | ECE2016

Macro, but not micrometastases, detected by OSNA technique are related with more aggressive papillary thyroid cancer features

Zafon Carles , Iglesias Carmela , Gonzalez Oscar , Temprana Jordi , Caubet Enric , Garcia-Burillo Amparo , Obiols Gabriel , Serres Xavier , Mesa Jordi

Introduction: Classically, risk stratification in papillary thyroid carcinoma (PTC) assigned the same magnitude of risk to all patients with regional lymph node involvement (N1 disease). However, specific lymph node characteristics (such as size, number, extension, etc.) will allow individualizing treatment and follow-up. One-Step Nucleic Acid Amplification (OSNA) measures the number of copies of mRNA of cytokeratin 19 (CK19) as a marker of lymph node metastasis. Thus, copy nu...

ea0049ep944 | Pituitary - Clinical | ECE2017

Acromegaly and cardiovascular risk

Biagetti Betina , Aulinas Anna , Lopez Natividad , Garcia-Fernandez Esther , Arnau-Vives Maria Jose , Ciudin Andrea , Obiols Gabriel , Dalama Belen , Mesa Jordi

Background: Acromegaly (ACRO) is associated with increased cardiovascular morbidity and mortality, however, there is no evidence of an increase in ischemic heart disease in these patients. We hypothesized that non-classical cardiovascular risk factors such as epicardial fat (EF), interventricular septum thickness (IST), carotid intima-media thickness (CIMT), may be increased in ACRO and contribute to this higher cardiovascular morbidity.Objective: To eva...

ea0041ep262 | Clinical case reports - Pituitary/Adrenal | ECE2016

Left adrenal Ectopic cushing syndrome even more challenging

Biagetti Betina , Simo Olga , Ortiz Angel , Iglesias Carmela , Dalama Belen , Obiols Gabriel , Castell-Conesa Joan , Gracia-Burillo Amparo , Caubet Enric , Mesa Jordi

Background: The Ectopic ACTH Syndromes (EAS) often associated with severe hypercortisolism are really a challenge.Case presentation: We report the case of a 48-year-old woman, newly diagnosed with hypertension, hypokalemia despite renin-angiotensin blockers intake, and complaints of intense fatigue, muscular weakness, and easy bruising, which worse in four months. EAS was biochemically confirmed, but two urinary catecholamines collection were negatives d...

ea0037gp.24.04 | Thyroid–genetics | ECE2015

Lymph node involvement using one-step nucleic acid amplification according to BRAF gene mutation status in patients with papillary thyroid carcinoma submitted to lymph node dissection

Zafon Carles , Gonzalez Oscar , Temprana Jordi , Obiols Gabriel , Garcia-Burillo Amparo , Serres Xavier , Balibrea Jose Maria , Castell Joan , Mesa Jordi , Iglesias Carmela

Introduction: The relationship between the BRAF gene mutation in papillary thyroid cancer (PTC) and the presence of lymph node metastasis (LNM) is a subject of controversy.Objective: To analyse the influence of BRAF mutation status in the characteristics of lymph nodes in patients with PTC submitted to lymph node dissection (LND).Material and methods: Lymph nodes obtained from 20 patients (12 females, mean age 50±15 y...