Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep65 | Adrenal and Cardiovascular Endocrinology | ECE2022

False positive metanephrines in high risk patient for pheochromocytoma

Fonseca Ricardo , Roque Catarina , Osorio Ana Sofia

BackgroundFalse positive results are common in the screening of pheochromocytoma. Even in high risk patients with disorders related to multiple endocrine neoplasia it’s crucial to exclude possible interferences with analytical methods.Clinical caseA 69 year-old man was submitted to total thyroidectomy, due to a 11 mm hypoechogenic nodule suspicious of papillary carcinoma (FNA). Histology confirmed medull...

ea0081ep92 | Adrenal and Cardiovascular Endocrinology | ECE2022

Very high urinary free cortisol levels in patients treated with tuberculostatics

Roque Catarina , Osorio Ana Sofia , Fonseca Ricardo

Introduction: Pharmacologically induced false positive results in urinary free cortisol levels (UFCL) have been ascribed to 11βHSD-2 inhibition or direct interference on HPLC. Few drugs have been implicated by mechanisms not yet confirmed.Case Reports: We report 3 patients with active pulmonary tuberculosis (TB) and very high UFCL, 2-6× above the upper limit of reference [mean levels 3411 μg/24 h (RR 167-827)]. The 2 males and the woman ag...

ea0063p915 | Diabetes, Obesity and Metabolism 3 | ECE2019

Profile of patients using continuous subcutaneous insulin infusion in portugal

Osorio Ana Sofia , do Vale Sonia , Cruz Diogo

Introduction: Continuous subcutaneous insulin infusion (CSII) represents a treatment option that helps patients with type 1 diabetes (PwT1D) to achieve better glycemic control, reduces hypoglycemia and improves quality of life. In Portugal, the National Health System (SNS) affords CSII treatment to PwT1D, according to certain criteria. Over the years, the number of patients treated with CSII devices supported by SNS has grown exponentially. We analyzed these patient’s pro...

ea0081p636 | Endocrine-Related Cancer | ECE2022

Struma ovarii with NIFTP tumor: case report

Osorio Ana Sofia , Fonseca Ricardo , Roque Catarina , Gasparinho Gabriela , Abrantes Sara

Struma ovarii is a form of mature teratoma, a rare germ cell tumor, containing more than 50% thyroid tissue. Malignancy is uncommon. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) inside struma ovarii was never described. A 32 y.o. female with previous history of ovarian cysts was admitted in the emergency room with painfull acute abdominal distention. The MRI revealed a right adnexal mass, predominantly cystic with 82x66x80 mm and surrou...

ea0090ep183 | Calcium and Bone | ECE2023

Severe hypocalcemia during respiratory alkalosis reveals a case of Pseudohipoparathyroidism type 1B

Roque Catarina , Fonseca Ricardo , Osorio Ana Sofia , Oliveira Sofia , Machado Catarina

We present a case of Inactivating PTH/PTHrP signalling disorder (IPPSD) revealed in aduthood in the context of respiratory alkalosis caused by covid-19 infection that led to worsening of the preexisting hypocalcemia and intensification of the usual hypocalcemic symptoms. A 39 year old female with history of subclinical hypothyroidism and bilateral cataracts was admited due to hypoxemia in the context of severe covid-19 infection with bilateral pulmonary infiltrates. She was vi...

ea0063p1177 | Thyroid 3 | ECE2019

Single thyroid amyloidosis: a case report

Osorio Ana Sofia , Barbosa David , Nobre Ema , Marques Tiago , Cantiga Paulo

Introduction: Thyroid amyloidosis is defined as amyloid protein and fat deposition within the thyroid gland. It is classified as either primary (idiopathic) or secondary to inflammatory/chronic disease. Albeit deposition of amyloid protein in thyroid tissue is frequent, amyloidosis affecting exclusively the thyroid gland without evidence of other organs involved is extremely rare. We report a clinical case of a patient who underwent lobectomy due to a toxic adenoma, whose hist...

ea0049gp237 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Thyrotoxic Periodic Paralysis due to Graves’ disease: a mandatory differential diagnosis in Asian patients presenting with paralysis and hypokalemia

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Vilas Ana Paula , Bugalho Maria Joao

Introduction: Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of hyperthyroidism that is underdiagnosed and frequently missed. It is relatively common in Asian men with Graves’ disease. TPP attacks are frequently associated with hypokalemia.Case presentation: We describe a 26-year-old Asian male with an unremarkable past medical history who was admitted following sudden onset of flaccid paralysis of the lower extre...

ea0049gp239 | Thyroid Cancer & Thyroid Case Reports | ECE2017

Renal cell carcinoma metastasis to thyroid tumor: a case report

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Subacute thyroiditis (SAT) association with papillary thyroid carcinoma (PTC) has been rarely reported in the literature. Metastatic neoplasms to the thyroid are rare in clinical practice. Renal cell carcinomas (RCC) are the most frequent site of origin of thyroid metastases (12 to 34%). Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. Tuberous sclerosis (TS) is associated with several renal manifestat...

ea0049ep95 | Adrenal medulla | ECE2017

Biochemical testing for pheochromocytoma

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Sampaio Joaquim , Bugalho Maria Joao

Introduction: Biochemical testing for Paraganglioma/Pheochromocytoma (PGL/PHEO) is recommended in patients with classical symptoms, in those harbouring an adrenal incidentaloma and in patients who have a hereditary risk for developing a PGL/PHEO. Measurements of plasma free metanephrines and/or urinary fractionated metanephrines provide a highly sensitive test for diagnosis but false-positive results remain a problem.Aim: Comparative analysis of plasma a...

ea0049ep320 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid nodular hyperplasia: when imaging exams fail

Osorio Ana Sofia , Rocha Jose , Faria Carolina , Barbosa David , Nobre Ema , Bugalho Maria Joao

Introduction: Parathyroid hyperplasia is the second cause of primary hyperparathyroidism (PH), representing 15–20% of all cases. The scintigraphy with Tc-99m-Sestamibi is a preoperative exam used to identify parathyroid adenomas or hyperplasia. It has a sensibility of 50–90%, which increases with larger parathyroid size. The neck ultrasonography (US) has also an important role detecting parathyroid enlarged glands with 70% sensibility. We report a case of parathyroid...