Endocrine Abstracts

The partum period can be seen as a transient condition of “menopause” due to the physiological decline to a baseline of the high estrogens found during pregnancy, and bone metabolism is likely to alter. Moreover, high calcium requirements for fetal growth and during breastfeeding are covered in the maternal metabolism from enhanced intestinal absorption in a Calcitriol dependent pathway, and maternal bone reabsorption under control of parathyroid hormone (PTH) parath...

We report the case of a middle age woman with the first presentation in our clinic for recurrence of hypercalcemia following surgery for parathyroid adenoma.Her personal history was positive for chronic thyroiditis and with long lasting asymptomatic hypercalcemia not exceeding 11 mg /dL for total plasmatic calcium since 2006. In 2011 her hypercalcemia was worsened (maximum level 13.49 mg/dL) and she was diagnosed with primary hyper...

We report the case of a middle age woman with the first presentation in our clinic for recurrence of hypercalcemia following surgery for parathyroid adenoma.Her personal history was positive for chronic thyroiditis and with long lasting asymptomatic hypercalcemia not exceeding 11 mg /dL for total plasmatic calcium since 2006. In 2011 her hypercalcemia was worsened (maximum level 13.49 mg/dL) and she was diagnosed with primary hyper...

We report a 21-year-old man who referred to endocrinologist following biopsy of a left-sided cervical mass. The pathological examination was diagnostic for medullary thyroid carcinoma (MTC). Physical examination was remarkable for a firm 3-cm nodule in right thyroid lobe and another 3 cm. firm nontender mass in left thyroid lobe. The calcitonin was 15,324 pg/ml, and carcinoembryonic antigen was 415 ng/ml. The calcium level was 10.3 mg/dl (<10 mg/dl) with unsuppressed parat...

We report a case of a 25 years old woman – with central transient hypoadrenalism after the right adrenalectomy for Cushing syndrome. She became pregnant 1 year after surgery while still taking a small dose of cortisol replacement therapy (5 mg Hydrocortisone) for partial recovery of her corticotrophic axis. Her pregnancy has been complicated by gestational diabetes, with good metabolic control under small doses of basal insulin. She increased her substitutive therapy at 2...

Introduction: The female genital developmental defects are not common in non-classical congenital adrenal hyperplasia (CAH). The causes of amenorrhea are multifactorial and are due to the incomplete control of hyperandrogenism as well as the increased progesterone, acting in various modes: blunted LH mid-cycle surge, lack of progestin withdrawal action and antagonise the estradiol action on the endometrium. The overtreatment with glucocorticoid results in the suppression of go...

Erythrocytosis is classified as either primary or secondary. Polycythemia vera (PV), a myeloproliferative neoplasm, is often caused by a mutation in exon 12 of the Janus kinase 2 (JAK2) tyrosine kinase gene which phosphorylates erythropoietin receptor (EPO-R) at multiple sites. Secondary erythrocytosis mainly results in conditions with increased erythropoietin (EPO) production. We report a 21-year-old man with metastatic medullary thyroid carcinoma (MTC) at diagnosis. The tota...

Evaluation of the thyroid function in pregnant women is of extreme importance for maternal and neonatal health. The reference interval of thyroid function tests in pregnant women differs from that of the general population and among trimesters in the same patient. Trimester-specific thyrotropin (TSH) reference ranges for pregnant women are recommended in order to avoid misclassification of the thyroid dysfunction during pregnancy.Less data about the free...