Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep582 | Endocrine-Related Cancer | ECE2022

A personalised approach to tracking circulating cell free tumour derived DNA in a patient with adrenocortical carcinoma

Gohil Shailesh , Page Karen , Hastings Rob , Shaw Jacqui , Levy Miles

Introduction: Adrenocortical carcinoma (ACC) is rare, with an incidence of 0.5-2 cases per million. Although generally aggressive, prognosis is highly variable and difficult to predict. Unlike other malignancies, there are no biomarkers routinely available for use in patients with ACC to help guide management. Circulating cell free tumour derived DNA (ctDNA), the proportion of circulating cell free DNA (cfDNA) originating from tumour cells, is a liquid biopsy that is quickly g...

ea0080OC2 | Oral Communications | UKINETS2021

Tracking circulating cell free tumour derived DNA in patients with neuroendocrine neoplasms

Gohil Shailesh , Page Karen , Hastings Rob , Iwuji Chinenye , Richards Cathy , Shaw Jacqui , Levy Miles

Introduction: There is a clinical need to develop novel and better biomarkers to monitor patients with neuroendocrine neoplasms (NENs). Our aim was to identify and track plasma circulating cell free tumour derived DNA (ctDNA) in a cohort of patients using a personalised, patient specific approach.Materials and methods: 35 serial plasma samples were collected from 9 patients with metastatic NENs (6 small intestinal and 1 each of lung, ovarian, and pelvic;...