Searchable abstracts of presentations at key conferences in endocrinology

ea0021cm4.2 | The management of thyroid cancer | SFEBES2009

Surgical treatment of thyroid cancer

Palazzo Fausto

Thyroid cancer is the commonest endocrine cancer. It is increasingly diagnosed both due to the diagnosis of previously undiagnosed subclinical lesions as well as due to a lesser true increase in incidence. Surgery is the only treatment modality that can cure thyroid cancer and has a key role in the multidisciplinary treatment of the malignancy. The combination of the rarity of the disease and broad spectrum of clinical outcomes has hindered the accumulation of level 1 evidence...

ea0018p12 | (1) | MES2008

Cushing's syndrome secondary to adrenocortical carcinoma without metastases at diagnosis

Miras Alexander , Palazzo Fausto , Naqvi Safdar

A 60-year-old gentleman of previously good health presented with a 6 months history of resistant hypertension, newly diagnosed Diabetes Mellitus, worsening obesity and proximal muscle weakness. Clinical examination revealed a buffalo hump, truncal obesity, paper thin skin with bruising and proximal muscle wasting. His biochemistry showed elevated midnight cortisol levels, no suppression of cortisol post high dose dexamethasone and an undetectable ACTH. Accompanying abnormaliti...

ea0015p340 | Thyroid | SFEBES2008

How useful is post-operative PTH at predicting hypocalcaemia following thyroidectomy?

Sharma Nidhi , Meeran Karim , Palazzo Fausto

Background: Post-operative hypocalcaemia affects up to 30% of patients. It may be delayed to the second or third post-operative day and is therefore the key determinant of post-operative stay. Various strategies have been used to overcome this problem including the blanket administration of calcium and discharge followed by daily blood tests.Objectives: To evaluate the use of using a parathyroid hormone (PTH) assay 4 h following surgery as a predictor of...

ea0052p42 | (1) | UKINETS2017

Therapeutic options in metastatic phaeochromocytomas

Mills Edouard , Dina Roberto , Palazzo Fausto , Sharma Rohini , Wernig Florian

Phaeochromocytomas are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. We report a 68-year-old female who was found to have a locally arising colonic adenocarcinoma on biopsies. Staging also identified a 10.7 cm right adrenal lesion and work-up revealed markedly raised urinary metanephrines and positive MIBG imaging. The MDT decision was to first remove the colonic cancer with appropriate alpha blockade. It was felt that a comb...

ea0050ep005 | Adrenal and Steroids | SFEBES2017

A rare occurence of adrenal leiomyosarcoma

Sharma Aditi , Lewington-Gower Elisa , Palazzo Fausto , Pokrajac Ana

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an inci...

ea0050ep103 | Thyroid | SFEBES2017

Severe thyroid-associated orbitopathy manifesting two years post total thyroidectomy for follicular carcinoma variant of the thyroid

Ramli Rozana , Palazzo Fausto , Robinson Stephen , Lee Vickie

We present a case of severe thyroid-associated orbitopathy in a 44-year-old man with metastatic follicular carcinoma of the thyroid. He presented with a neck lump, and following further investigations, underwent a hemithyroidectomy followed by a completion thyroidectomy. Histology of the thyroid confirmed widely invasive follicular carcinoma of Hurthle cell type with foci of vascular invasion (pT3 Nx Mx). He received radioactive iodine ablation therapy (3.7GBq), ...

ea0050ep005 | Adrenal and Steroids | SFEBES2017

A rare occurence of adrenal leiomyosarcoma

Sharma Aditi , Lewington-Gower Elisa , Palazzo Fausto , Pokrajac Ana

Leiomyosarcoma is a rare, malignant tumour that can arise from smooth muscle cells anywhere in the body; common sites include uterus, GI tract and retroperitoneum. We report an unusual case of a patient with an adrenal incidentaloma confirmed as a leiomyosarcoma on histology.A 61-year-old Caucasian female was investigated for chronic abdominal pain. CT scan of the abdomen and pelvis did not show any pathology other than an inci...

ea0050ep103 | Thyroid | SFEBES2017

Severe thyroid-associated orbitopathy manifesting two years post total thyroidectomy for follicular carcinoma variant of the thyroid

Ramli Rozana , Palazzo Fausto , Robinson Stephen , Lee Vickie

We present a case of severe thyroid-associated orbitopathy in a 44-year-old man with metastatic follicular carcinoma of the thyroid. He presented with a neck lump, and following further investigations, underwent a hemithyroidectomy followed by a completion thyroidectomy. Histology of the thyroid confirmed widely invasive follicular carcinoma of Hurthle cell type with foci of vascular invasion (pT3 Nx Mx). He received radioactive iodine ablation therapy (3.7GBq), ...

ea0065p11 | Adrenal and Cardiovascular | SFEBES2019

Cosyntropin stimulation test post unilateral adrenalectomy for non-steroid secreting lesions: not all who fail require steroids

Zaman Shamaila , Almazrouei Raya , DiMarco Aimee , Palazzo Fausto , Wernig Florian

Aim: Recent studies reported a wide range in baseline and peak cortisol responses to surgery. We report the results of cosyntropin stimulation testing following unilateral adrenalectomy for non-steroid secreting lesions.Methods: Data of 36 patients who underwent cosyntropin stimulation testing on the second day post unilateral adrenalectomy were collected retrospectively. None of the patients had clinical signs of hypercortisolism. No patient received pr...

ea0065p95 | Bone and calcium | SFEBES2019

A case of successful parathyroidectomy in the third trimester of pregnancy

Sanderson Miriam , Kostoula Melina , Palazzo Fausto , Boret Tony , Kong Chantal

Primary Hyperparathyroidism (pHPT) affects approximately 1:2000 women under 40 years of age, so pHPT in pregnancy is uncommon. It is associated with significantly increased risks of morbidity for mother and foetus. Conventionally, surgery is recommended, ideally early in the second trimester. A 31-year-old woman attended the Accident and Emergency department at 26+4 weeks of her third gestation, with severe loin pain and fever. She had a past medical history of pyelonephritis....