Endocrine Abstracts

Introduction: Ovarian cancer is the most lethal gynecological malignancy. Early diagnosis has a survival rate of 90%. Unfortunately, more than 70% of cases are diagnosed when the cancer has already metastasized, and survival rates do not exceed 30% in these cases. The sodium iodide symporter (NIS) is an integral plasma membrane glycoprotein expressed in the basolateral surface of the thyroid gland, where it mediates active transport of iodide. Radioiodide therapy (RAI) through...

Introduction: In the treatment of amiodarone-induced type I or mixed thyrotoxicosis, sodium or potassium perchlorate is often associated to thionamides, when the latter are insufficient for a prompt control of thyroid hormone secretion. Perchlorate competes with iodine for entrance into the follicular cell, and also induces a discharge of iodine from these cells with each administration. We compare the effect of 3 different regimes of perchlorate with methimazole on control of...

Introduction: Post-surgical hypoparathyroidism (PSHP) is a frequent complication following ENT surgery. Some patients with head/neck cancers require enteral nutrition (EN) due to dysphagia, mucositis after radiotherapy or chemotherapy, or post-surgical anatomical complications. Formulas of calcitriol are not suitable to be administered via enteral feeding tubes, and side effects of systemic antineoplastic treatment (nausea, vomiting) make calcium and phosphate serum levels dif...

IntroductionThe number of lymph node metastasis (NM) and the existence of extranodal extensión (ExEx) are not included among prognosis variables used in the most common staging systems for differentiated thyroid cancer as AJCC and ATA risk systems.ObjectiveIn patients with NM at diagnosis, to analyze the association between the number of NM and the presence of ExEx with response to therapy.<p class="...