Endocrine Abstracts

A young woman aged 23 years, with non-toxic goiter was treated in our Department. Serum levels of FT4, FT3 and TSH were within normal range, high resolution ultrasonography show very large glands (60 ml), with large nodule in left lobe and smaller one in the right lobe. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. Thyroid radioiodine scintigraphy showed homogenous and diffuse uptake in the right lobe, with very low uptake i...

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the reduction of thyroid volume after pre-treatment adjunct of rhTSH in patients with non-toxic goitre with low RAIU.Material and methods: We treated 36 patients; (28 female, 8 male) aged 35–77 years. Initial 24 h RAIU was ranged between 5 and 17%, and thyroid volume ranged between 42 and 128 ml. Twelve patients had compressive symptoms. Malignant changes were exclu...

Aim: The aim of our study was to evaluate the short-term (5 years) effect of radioiodine therapy (RAIT) on the achievement of euthyroidism, and prevention evolvement to overt hyperthyroidism.Material and methods: We treated 150 patients, aged 30–70 years; 54 patients with multinodular goitre (MNG), and 96 patients with autonomous nodule (ATN). Malignant changes were excluded in all nodules by fine needle aspiration biopsy. All the patients had serum...

Oxidative stress plays an important role in hyperthyroidism induced – tissue damage.We aimed to determine whether radioiodine therapy (RIT) has benefit effect on the oxidant and antioxidant status in subclinical hyperthyroidism.Material and methods: We studied 40 patients with untreated subclinical hyperthyroidism, (33 female, 7 male), aged 23–78 years; 14 patients with multinodular goitre, and 25 patients with solitary a...

The aim of our study was to assess the effectiveness of radioiodine therapy (RIT) on the achievement of euthyroidism and reduction of thyroid volume, in patients with toxic nodular goitre (TNG).Material and methods: During the last 7 years, we treated 3800 patients with TNG, aged 30-70 years; 82% female and 18% male; 2200 patients with multinodular goitre (MNG) and 1600 with autonomous toxic nodule (ATN); thyroid volume ranged between 16 and 130 ml (30% ...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and skeletal systems and prevent evolvement to overt hyperthyroidism.Material and methods: We treated 630 patients, aged 30–70 years; 85% of them were female and 15% male; 220 patient with multinodular goitre (MNG), and 310 patient with autonomous nodule (ATN). Some of the p...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage.We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with toxic nodular goitre.Material and methods: We studied 40 patients with toxic nodular goitre, (31 female, 9 male), aged 21–65 years. 12 normal adult volunteers (age and sex-matched) were studied as control group. All the pati...