Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1106 | Neuroendocrinology | ICEECE2012

Insulin improves memory and cognition via protein kinase c delta (δ)

Apostolatos A. , Cooper D. , Patel N.

Older population and people with type II diabetes have a significantly higher rate of decline in cognitive function. However, the mechanisms are poorly understood. There are strong links between insulin and cognitive function supported by epidemiological data from humans and animal studies and in vitro research. Protein kinase C (PKC) signaling cascades and insulin pathways are closely integrated. The consequences of PKC activation by insulin in the CNS influence memory...

ea0008p90 | Thyroid | SFE2004

The Irrelevance of Anti-thyroid Peroxidase Antibodies

Toumadj N , Patel NH , Meeran K

Anti-thyroperoxidase autoantibodies (TPOAb) are one of the major secondary autoantibodies associated with AITD. Many endocrine hospital referrals are received for patients with elevated TPOAb levels without other disordered thyroid function tests.This study aimed to investigate the use of TPOAb testing in hospital practice, to determine whether the presence or absence of TPOAb indicates the existence of thyroid disease and the effect of the TPOAb result ...

ea0005oc17 | Obesity and Diabetes | BES2003

Autocrine FGF-2 is essential for human preadipocyte differentiation

Patel N , Kumar S , Eggo M

Preadipocytes differentiate into mature adipocytes when treated with insulin, T3, isobutylmethylxanthine and dexamethasone but the role of their autocrine factors in their survival and function has only recently been appreciated. We have examined the expression and role of autocrine FGF-2 during preadipocyte differentiation. Using human preadipocytes isolated from subcutaneous fat, we induced differentiation in differentiation medium with and without the insulin-sensitising dr...

ea0004p29 | Cytokines and growth factors | SFE2002


Patel N , Lowy C , Carr R , Jupp R , Wheeler M

Acute critical illness has an effect on normal physiology resulting in changes in the inter-relations of the endocrine system.Evidence suggests that these changes may be due to the pro-inflammatory cytokines (e.g. interleukin-6 (IL-6)), which are known to have a paradoxical effect on the hypothalamo-pituitary axis, stimulating the adrenal axis, whilst suppressing the remaining axes.Multiple myeloma (MM) patients have elevated IL-6 ...

ea0003p242 | Signalling | BES2002

Essential role of p38 mitogen-activated protein kinase in adipogenesis

Patel N , Holder J , Smith S , Kumar S , Eggo M

Human obesity is characterised by an increase in both the number of adipocytes and by an increase in their size, which is determined by adipogenesis. Adipogenesis can be induced in vitro in preadipocytes cultured in differentiation medium containing 3-isobutyl-1-methylxanthine, insulin, dexamethasone, and triiodothyronine but the signalling pathways important in adipogenesis are not well characterised. The p38 mitogen-activated protein kinase (MAPK) signalling pathway i...

ea0019oc21 | Cardiovascular metabolism | SFEBES2009

Cerebellin1 is a novel orexigenic factor which potently increases food intake via hypothalamic neuropeptide Y release

Roy D , Dhillo W , Gardiner J , Bataveljic A , Campbell D , Patel N , Ghatei M , Bloom S

Background: The hypothalamus is a critical area of the brain involved in the regulation of appetite. Cerebellin1 (Cbln1) is a highly conserved 16 amino acid neuropeptide. High levels of Cbln1 mRNA expression are found in specific hypothalamic areas involved in appetite regulation.Aim: To examine the effects of Cbln1 on food intake in rodents.Methods: 1. Ad libitum fed rats were injected intracerebroventricularly (ICV) with Cbln1 (1...

ea0019oc20 | Cardiovascular metabolism | SFEBES2009

The novel peptide prokineticin-2 potently inhibits food intake in rodents and is a potential novel anti-obesity therapy

Bataveljic A , Gardiner J , Patel N , Bewick G , Roy D , Cooke J , Campbell D , Semjonous N , Murphy K , Hameed S , Prosser H , Jethwa P , Ebling F , Vickers S , Cheetham S , Maleuwe P , Ghatei M , Bloom S , Dhillo W

Background: The novel peptide prokineticin-2 (PK2) has recently been implicated in the regulation of a number of physiological processes; including regulating gastrointestinal motility, spermatogenesis, neurogenesis and circadian rhythms. PK2 is a cysteine rich protein which mediates its effects via the prokineticin receptors which are expressed in several hypothalamic nuclei known to regulate food intake. We therefore hypothesised that PK2 may be an important endogenous regul...