Endocrine Abstracts

Introduction: Differentiated thyroid cancer (DTC) is rare in the paediatric population when compared to adults. Paediatric patients often present with advanced disease at diagnosis, characterized by multifocal disease, heightened lymph node involvement, and distant metastasis. Additionally, they face a higher risk of post-operative complications in comparison to adults. Despite that, paediatric DTC exhibits an excellent prognosis.Methods: A retrospective...

Introduction: Adrenocortical carcinoma is a rare type of cancer that usually has a dismal prognosis. The concurrent hormonal excess of some of these tumours can have an additional negative impact on patients´ morbidity and mortality.Clinical Case: We present the case of a 57-year-old woman diagnosed with stage IV adrenocortical carcinoma, with liver and bone metastasis, and associated ACTH-independent Cushing syndrome and hyperandrogenism. The patie...

Introduction: Pancreatic neuroendocrine tumors (PNETs) originate from neuroendocrine islet cells and can therefore secrete several neuropeptides. Multiple and secondary hormone secretion have been described in a minority of cases, mostly with advanced disease, and it has been hypothesized that this complex secretion pattern can serve as a marker for tumor behavior.Case report: Male patient, 69 years old, diagnosed with a glucagonoma with pulmonary and he...

Introduction: Immunossupression is a possible consequence of hypercortisolism, putting these patients in a state of increased risk of infections.Case report: Female, 19 years old. In July 2014 she seek for medical care because she became feverish and developed an erythematous rash on her face/trunk with subsequent widespread to the entire body. She was admitted in the ICU with the diagnosis of severe varicella with acute cholestatic hepatitis and conflue...

Introduction: The best timing for PRRT (peptide receptor radionuclide therapy) in the case of pancreatic neuroendocrine tumors (panNETs) is still to define, as randomized prospective trials are lacking. Recent studies suggest that some systemic therapies can affect response to PRRT, favoring an earlier use of the latter.Objective: To determine the efficacy and toxicity of PRRT, comparing its results when used as a second line systemic therapy (a...

Neuroendocrine neoplasms (NENs) arise from specialized cells called neuroendocrine cells spread through the body, mainly in the gastrointestinal tract, pancreas and lung. Pathological classification of Lung NENs include well differentiated NENs, that can be classified as typical or atypical carcinoids, and poorly differentiated neuroendocrine carcinomas (NECs), classified as small-cell lung carcinoma (SC-NEC) or large-cell neuroendocrine carcinoma (LC-NEC). We present a case o...

Introduction: The Neuroendocrine Tumors Study Group of the Portuguese Endocrine Society (SPEDM) performed the first observational study between November 2012 and July 2014 too assess the profile of Gastroenteropancreatic Neuroendocrine Tumours (GEP-NET) patients (pts) followed at the main Portuguese hospitals. Several demographic and clinical data were collectedObjective: Characterize the clinicopathological features and treatment of patients with NET or...