Searchable abstracts of presentations at key conferences in endocrinology

ea0005p183 | Neuroendocrinology and Behaviour | BES2003

Serum leptin, insulin, IGF-1 levels and body composition in partially and fully recovered patients with anorexia nervosa

Djurovic M , Petakov M , Damjanovic S , Pekic S , Glisic B , Miljic D , Doknic M , Dieguez C , Casanueva F , Popovic V

The variables which might affect the reproductive function in recovered patients with anorexia nervosa (AN) were investigated. We studied 12 patients with partially (n=6) and fully recovered AN (n= 6). They were matched for age (22.5 plus/minus 1.8 vs. 23.2 plus/minus 1.7 yrs; p>0.05), body weight (50.3 plus/minus 2.1 vs. 56.7 plus/minus 2.3kg; p>0.05) and BMI (19.7 plus/minus 0.2 vs. 20.3 plus/minus 0.6 kg/m2, p>0.05). Partially recovered AN were amenorrhoeic while f...

ea0029p1429 | Pituitary Clinical | ICEECE2012

Synergistic effects of combined stimulation with CRH+ghrelin on ACTH and cortisol responses in patients with Cushing’s disease: a pilot study

Miljic D. , Doknic M. , Pekic S. , Stojanovic M. , Damjanovic S. , Popovic V.

Background: Several stimulatory tests for differential diagnosis of ACTH dependent CushingÂ’s syndrome are avilable, CRH being the most valuable test in patients with CushingÂ’s disease (CD). Exaggerated responses to ghrelin have also been shown in patients with CD mainly due to overexpression of GHS receptors on corticotrope tumor cells. However, the effects of combined stimulation with CRH+ghrelin on ACTH and cortisol secretion have not been tested before in these pa...

ea0026p46 | Endocrine disruptors | ECE2011

Bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone

Doknic M , Bojovic N Maric , Pekic S , Britvic D , Damjanovic A , Gasic M Jasovic , Popovic V

Introduction: Studies suggest that schizophrenia and prolactin raising antipsychotics, one of them being risperidone, may be associated with low bone mass. On the other hand, weight gain as a consequence of antipsychotics in these patients may be the protective factor against osteoporosis.Objective: Determine bone remodeling parameters and bone mass in patients with schizophrenia treated with long-acting injectable risperidone (LAIR) under naturalistic c...

ea0026p173 | Neuroendocrinology | ECE2011

Glucose homeostasis in GH deficient adults not treated with GH: more than 10 year follow-up

Djurdjevic S Pekic , Doknic M , Stojanovic M , Miljic D , Djurovic M , Stojanoska M Medic , Popovic V

Study objective: We investigated prevalence of impaired glucose homeostasis in a large cohort of adult patients with GH deficiency (GHD), not treated with GH after more than 10 years of follow-up.Design: Seventy-one adult GHD patients (30 males, 41 females; mean age 48.3±2.0 years, mean BMI 28.8±0.7 kg/m2, GH deficient for 10.2±1.2 years) were evaluated. Ninety percent of patients had multiple pituitary hormone deficiencies whic...

ea0010oc21 | Young Endocrinologist session | SFE2005

Neuroendocrine response to ghrelin in patients with anorexianervosa (AN)

Miljic D , Pekic S , #Djurovic|# , Doknic M , Milic N , Casanueva F , Ghatei|V##Popovic M

Ghrelin stimulates growth hormone (GH), prolactin (PRL) and cortisol release in rodents and healthy humans.Aim: to determine the effects of ghrelin on neuroendocrine response in patients with AN in this cross-sectional hospital based study, approved by the Local Ethical Committee. Twenty-five young women were studied: AN with very low body weight (BMI 12.0±0.4 kg/m2), partially recovered AN (PRAN 17.2±1.3 kg/m2) and consti...

ea0007p121 | Endocrine tumours and neoplasia | BES2004

Discrepancies between current consensus criteria for cure after transsphenoidal surgery for acromegaly

Petakov M , Djurovic M , Miljic D , Doknic M , Pekic S , Popovic V , Damjanovic S

The short-term results of transsphenoidal surgery as initial treatment for acromegaly were analyzed according to consensus defining the criteria for cure of acromegaly.Thirty nine newly diagnosed patients with acromegaly (20 females and 19 males, mean age 46.9 plus/minus 1.4 years, range 29-66 yrs), underwent transsphenoidal pituitary adenomectomy by the same neursurgeon. Patients have been assessed postoperatively at 8 weeks (GH after 75 g oral glucose ...

ea0029p1145 | Neuroendocrinology | ICEECE2012

Relationship between leptin, markers of bone turnover, bone mineral density, and body weight in patients with schizophrenia treated with long acting risperidone (LAIR)

Doknic M. , Maric N. , Britvic D. , Pekic S. , Miljic D. , Stojanovic M. , Damjanovic A. , Jasovic-Gasic M. , Popovic V.

Introduction: Leptin, adipose-tissue-derived hormone has a prominent role in bone remodeling by activating, through CNS relay, the sympathetic tone which inhibits bone formation. Schizophrenia is a CNS disease associated with low bone mass and changes in bone remodeling. Risperidone, atypical antipsychotic, may be related to increase in body weight (BW). Increased BW is thought to be protective to the bone.Aim: To determine relations between leptin, bone...

ea0011p304 | Diabetes, metabolism and cardiovascular | ECE2006

Serum ghrelin levels during oral glucose challenge – new insights from gastrectomized patients

Miljic D , Pekic S , Pesko P , Djurovic M , Doknic M , Glodic J , Dieguez C , Casanueva FF , Popovic V

Ghrelin is gastric peptide with appetite stimulating and growth hormone (GH) releasing properties. Circulating ghrelin levels decrease after nutrient ingestion, oral and iv glucose challenge. It has been hypothesized that vagal system may have a major role in initiating this decrease.The aim of this study was to investigate circulating ghrelin levels during oral glucose challenge in gastrectomized (GASTRX)- vagotomized patients. The study was approved by...

ea0011p560 | Growth and development | ECE2006

Growth without growth hormone: normal final height of four patients with multiple pituitary hormone deficiency

Doknic M , Miljic D , Pekic S , Djurovic M , Zivkovic V , Stojanovic M , Dieguez C , Casanueva FF , Popovic V

Normal linear growth in children is highly complex process, regulated by interaction of genetic, environmental and hormonal factors.We present four growth hormone deficient patients which despite severe growth hormone deficiency according to the provocative tests (ITT or GHRH+GHRP-6) and decreased IGF I level grew normally. This study was approved by Ethical Committee of University Clinical Center Belgrade. Three of our patients had idiopathic multiple p...

ea0011p603 | Neuroendocrinology and behaviour | ECE2006

Unrecognized chronic hypopituitarism in patients who survived hemorrhagic fever with renal syndrome

Stojanovic M , Pekic S , Cvijovic G , Kendereski A , Doknic M , Miljic D , Zivkovic V , Djurovic M , Micic D , Popovic V

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease caused by Hantavirus. One of the rare complications of this disease is hypopituitarism (only sporadically reported) due to hemorrhage, necrosis and atrophy of anterior pituitary lobe. The aim of the study was to investigate the anterior pituitary function in patients who recovered from HFRS.We evaluated 31 patients (29 male and 2 female), aged 38.7±2.2 years, with BMI 25.7±0...