Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep28 | Adrenal and Cardiovascular Endocrinology | ECE2021

Effects of sorafenib, a tyrosin kinase inhibitor, on adrenocortical cancer cell line

Cerquetti Lidia , Bucci Barbara , Raffa Salvatore , Lardo Pina , Maggio Roberta , Simonini Chiara , Petrangeli Elisa , Toscano Vincenzo , Pugliese Giuseppe , Stigliano Antonio

The lack of an effective medical treatment for adrenocortical carcinoma (ACC) has prompted the, search for better treatment protocols for ACC neoplasms. Sorafenib, a tyrosine kinase inhibitor has exhibited effectiveness in the treatment of different human tumors. Therefore, the aim of this study was to understand the mechanism through which sorafenib acts on ACC, especially since treatment with sorafenib alone is sometimes unable to induce a long-lasting antiproliferative effe...

ea0049ep702 | Obesity | ECE2017

Obesity, cardiomyopathy and anabolic hormones

Gangitano Elena , Costantini Daniela , Tozzi Rossella , De Giorgi Francesca , Poggiogalle Eleonora , Mariani Stefania , Petrangeli Elisa , Donini Lorenzo Maria , Barbaro G. , Gnessi Lucio , Lubrano Carla

Obesity is associated with hemodynamic alterations that may lead to heart failure (HF), through the development of cardiac structural abnormalities and impairment of ventricular function. Obesity-related neurohormonal and metabolic disturbances may predispose to HF, even in the absence of comorbidities. Excess adipose tissue and in particular visceral adiposity contributes to the altered production of a number of anabolic hormones also involved in the regulation of the cardiac...