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ea0032p974 | Steroid metabolism and action | ECE2013

Effects of food components and the ratio of epitestosterone to testosterone on steroid glucuronidation

Jenkinson Carl , Barker James , Petroczi Andrea , Naughton Declan

The ratio of the glucuronidated epitestosterone (E) and testosterone (T), used in doping tests, is currently under question. The key enzyme involved in E metabolism is UGT2B7 in contrast to T which is mainly metabolised by UGT2B17. Previous results demonstrated that at very high concentrations E acts as a competitive inhibitor to UGT2B17. Similarly, the literature reports competitive inhibition of UGTs by NSAIDS and phenolics that are not substrates of UGT2B17. The aim of this...

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ea0032p125 | Calcium and Vitamin D metabolism | ECE2013

An observational study reveals that neonatal vitamin D is primarily determined by maternal contributions: implications of a new assay on the roles of vitamin D forms

Karras Spyridon , Shah Iltaf , Petroczi Andrea , Goulis Dimitrios , Bili Helen , Papadopoulou Fotini , Anagnostis Panagiotis , Persinaki Aggeliki , Tarlatzis Basil , Naughton Declan

Introduction: Vitamin D concentrations during pregnancy are measured to diagnose states of insufficiency or deficiency. The aim of this study is to apply accurate assays of vitamin D forms (single hydroxylated (25(OH)D2, 25(OH)D3), double-hydroxylated (1α,25(OH)2D2, 1α,25(OH)2D3), epimers (3-epi-25(OH)D2, 3-epi-25(OH)D3)) in mothers (serum) and neonates (umbilical cord) i) to expl...

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Endocrine Abstracts

Effects of food components and the ratio of epitestosterone to testosterone on steroid glucuronidation

An observational study reveals that neonatal vitamin D is primarily determined by maternal contributions: implications of a new assay on the roles of vitamin D forms

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