Endocrine Abstracts

Phaeochromocytomas are catecholamine-secreting tumors that usually arise from the adrenal medulla. Catecholamine-secreting tumors may also develop in retroperitoneal, pelvic or thoracic paraganglia. Here, we use the term phaeochromocytoma for catecholamine-secreting adrenal or extra-adrenal tumors. Before 2000, 10 to 15% of the patients with phaeochromocytoma were reported to have family or phenotypic evidence of a hereditary disease: multiple endocrine neoplasia type 2 (MEN2;...

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Insuline like growth factor II (IGF II) is an important regulator of neoplastic growth and it is stromal in origin. Estrogen and Progesterone receptor (ER, PR) are considered a good prognostic predictors in BC. The aim of the study was to evaluate the impact of IGF II mRNA expression in the clinical outcome in breast malignancy. The study group included 75 women (mean age ±S.D.=53.3±15.6 yr) submitted to radical mastectomy for ductal infiltrating breas...

Thyroid autoimmunity and BC are strongly related, but the cause of this association is unknown. In BC an increase of lymphoid cell infiltrates may be detected very early during tumor development. BC cells share some antigenic properties similar to those detected in thyroid tissue, as NIS and peroxidase activity and it is possible that in patients with BC and thyroid autoimmunity, should be present serum immunoglobulins reacting with these specific antigenes.<p class="abste...

Recent in situ hybridization data showed high content of IGF-II mRNA in the stroma of breast cancer. The aim of this study was to examine the expression of IGF-II protein and its relationship with several prognostic parameters in 75 ductal infiltrating carcinoma (DIC) of the breast.The tissue sections were evaluated for IGF II protein, proliferating activity, ER, PR, p53, P21 oncogene expression using immunohistochemical procedures. The amoumt of ...

Objective: A potential role for the ketone body beta-hydroxybutyrate (β-OHB) has received increasing interest in the study of metabolic disease, but the association of β-OHB with Type 2 Diabetes (T2D) risk remains unclear. The present study aimed to explore the association of β-OHB with incident T2D in a prospective population-based cohort.Methods: We measured plasma concentrations of β-OHB using nuclear magnetic resonance spectroscop...

Tissue samples from adrenal tumors provide the basis for standard diagnostic procedures such as pathological examination. In addition, these tumor samples have been an invaluable source for the discovery of novel molecular pathways involved in adrenal tumorigenesis. Information on the molecular phenotype are based on DNA mutation analysis and epigenetic changes, RNA and protein expression pattern and sub-cellular localization as well as post transcriptional protein modificatio...

ObjectiveDue to the increasing prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), it has become a global health challenge by being the most common cause of chronic liver disease. Recently, the microbiota has been linked to NAFLD, via altered bile acid and lipid metabolism. Whether serum Trimethylamine-N-oxide (TMAO), a gut microbiota-dependent metabolite, is associated with NAFLD and NAFLD health outcomes remains unclear. The aim was to investigate...

Objective: Despite combination with peripheral decarboxylase inhibitors significant amounts of L-dopa are peripherally metabolised. In patients with Parkinson’s disease (PD) treated with L-dopa and a dopa decarboxylase inhibitor, urinary dopamine concentrations are markedly elevated. We describe here a L-dopa treated PD patient presenting with a clinical and biochemical picture suspicious of phaeochromocytoma.Case report: A 73-year-old female patien...

Surgical treatment is the first therapeutic option in patients affected with medullary thyroid carcinoma (MTC). However, cure-rates are often low due to the high frequency of loco-regional metastases and recurrences. Therefore, post-operative hyper-calcitoninemia is a common feature in CMT. Despite these findings, traditional imaging techniques are often unable to localize tumour foci. In the last years the availability of new morpho-functional techniques might offer new chanc...