Searchable abstracts of presentations at key conferences in endocrinology

ea0031p179 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

FGF21 action on human adipose tissue compromised by reduced βKlotho and FGFR1 expression in type 2 diabetes mellitus

Piya Milan K , Harte Alison L , Chittari Madhu V , Tripathi Gyanendra , Kumar Sudhesh , McTernan Philip G

Background/objectives: Fibroblast growth factor 21 (FGF21) is a potent hormone known to reduce glycaemia and improve insulin resistance with anti-obesity effects. Although mainly secreted in the liver, adipose tissue is considered an important target for its function. Whilst FGF21 has been shown to be expressed in murine adipose tissue, studies in human adipose tissue are lacking. Therefore our aim was to examine the expression of FGF21, FGF21 receptor-1 (FGFR1), βKlotho ...

ea0031p205 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Irisin as a central regulator in energy homeostasis?

Piya Milan K , Harte Alison L , Sukumar Kavitha , James Sean , Tripathi Gyanendra , Kumar Sudhesh , Vatish Manu , McTernan Philip G

Background/objectives: Irisin is a novel myokine, released predominantly by skeletal muscle. Peripheral action of irisin improves glucose homeostasis, increases energy expenditure and induces browning of adipocytes, with therapeutic potential for use in weight loss. However, there are no human studies on the central role of irisin in the regulation of appetite or energy expenditure. This study sought to examine the potential central role of irisin, by demonstrating irisin in h...

ea0038fp7 | (1) | SFEBES2015

Regulation of adipogenesis by wnt10b signalling in cultured human adipocytes taken from an obese patient with a WNT10B-C256Y mutation

Azharian Sahar , Voyias Philip D , Murphy Alice , de la Escalera Clapp Lucia Martinez , Adaikalakoteswari Antonysunil , Saravanan Ponnusamy , Piya Milan K , McTernan Philip G , Tripathi Gyanendra

Background: Adipogenesis is a key process leading to adipose tissue (AT) expansion. However, managing this event is critical to limit excessive fat accumulation and disease risk. Adipogenesis appears controlled in part, through Wnt10b signalling which reduces adipogenesis via inhibiting CCAAT/enhancer-binding protein alpha (CEBPα) although the molecular mechanism remains unclear.Aims: Abdominal subcutaneous AT (AbdSc AT) was collected from a, non-di...

ea0031p219 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Eating more quickly heightens overall systemic exposure to glucose and NEFA in the post-prandial phase, irrespective of energy expenditure in obese women

Reddy Narendra , Peng Chen , Piya Milan K , Aftab Saboor A S , Campbell Alison , Hattersley John , Halder Louise , Harte Alison L , Randeva Harpal , Tripathi Gyanendra , McTernan Philip G , Kumar Sudhesh , Barber Thomas M

Background/aim: The global obesity epidemic has promoted a search for novel solutions. One approach is through modification of eating-related behaviours. Our aim was to explore the effects of meal duration on energy expenditure, appetite and excursions of molecules associated with insulin sensitivity in the post-prandial phase.Methods: Normoglycaemic, pre-menopausal, Caucasian obese women (n=8) were recruited from the Obesity clinic at Warwicksh...