Endocrine Abstracts

A 60 year old gentleman with a history of renal stones presented 5 years ago with left sided flank pain. A CT of his renal tract showed an unexpected metastatic deposit in the left iliac crest. Cross-sectional whole body imaging, performed to locate the primary, also identified an expansile soft tissue mass in the T8 vertebral body and a predominantly cystic looking left sided thyroid nodule. He proceeded to have an iliac crest biopsy which was consistent with metastatic folli...

Case history: A 45 year old lady with Von Hippel Lindau syndrome with a complex past medical history presented with symptoms of cauda equina compression. Past medical history includes cerebellar hemangioblastomas, bilateral retinal angiomas, right sided renal cell carcinoma and renal carcinoid tumour treated with partial and then completion nephrectomy, bilateral phaeochromocytoma treated with bilateral adrenalectomy, metastatic neuroendocrine tumour treated with Whipple’...

Background: The measurement of thyroglobulin (Tg) is important in the follow-up of patients with differentiated thyroid cancer (DTC), but interpretation is subject to interference by anti-thyroglobulin antibodies (TgAb). National guidelines recommend measurement of TgAb status but no consensus exists on how surveillance should be adapted in cases of TgAb positivity.Aims: To evaluate the impact of TgAbs on clinical management, in a single-centre cohort of...

Introduction: 131I-MIBG is a well-established treatment modality for patients with neuroendocrine tumours (NETs). Our centre has now accumulated over 10 years of experience with 131I-MIBG therapy, with long term data to evaluate effects on disease progress and other long term outcomes following therapy. Bone marrow effects of radionuclide therapy may include prolonged suppression, myelodysplasia or even frank leukaemia. Incidence is thought to be low, but...

ObjectiveActive acromegaly is associated with increased mortality. While surgery is the mainstay of treatment, it is not always curative. In selected cases, CyberKnife stereotactic radiosurgery (CK SRS) can be used as adjuvant treatment in patients with persistent disease.DesignThis is a retrospective review of the biochemical and imaging characteristics for patients with active acromegaly treated with CK SRS...

Background: Patients being treated for differentiated thyroid cancer (DTC) receive a dose of Radioiodine for remnant ablation. Occasional patients appear to have little or no iodine uptake at all in the thyroid bed or else where even shortly after thyroidectomy.Objective: To evaluate the influence of ‘Coexisting Thyroiditis’ on radioiodine uptake in thyroid cancer ablation doses.Methods and Design: Retrospec...

Background: Patients being treated for differentiated thyroid cancer (DTC) receive a dose of Radioiodine for remnant ablation. Occasional patients appear to have little or no iodine uptake at all in the thyroid bed or else where even shortly after thyroidectomy.Objective: To evaluate the influence of ‘Coexisting Thyroiditis’ on radioiodine uptake in thyroid cancer ablation doses.Methods and Design: Retrospec...

Medullary thyroid carcinoma (MTC) is a rare malignancy which has often metastasised at time of diagnosis. Surgical resection represents the only prospect for cure. However, debulking neck surgery may be beneficial in advanced cases. Prophylactic surgery is increasingly undertaken in asymptomatic patients with known mutations in the RET oncogene. The aim was to describe the outcome following initial surgical treatment for MTC at our institution. We performed a retrospe...

Background: Phaeochromocytomas and paragangliomas are familial in up to 25% of cases and can result from succinate dehydrogenase (SDH) gene mutations.Objective: To describe the clinical manifestations of subjects with SDH-B gene mutations.Design: Retrospective case series.Patients: Thirty-two subjects with SDH-B gene mutations followed-up between 1975 and 2007. Mean follow-up of 5.8 years (S.D....