Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps2-08-68 | Thyroid Cancer BASIC | ETA2022

NOX-derived oxidative stress is high in neoplastic thyroid lesions and correlates with ata risk in papillary thyroid cancer

Pogliaghi Gabriele , Muzza Marina , Colombo Carla , Persani Luca , Fugazzola Laura

Oxidative stress (OS) can have an impact both in the pathogenesis and in the progression of TC, as it has been shown to induce oncogenes and inhibit tumor suppressors. The main source of cellular ROS is represented by NADPH oxidases (NOXs). Aims of the study were to investigate the NOX-derived OS in TC samples, benign nodules and corresponding normal tissues, and to correlate the level of OS with histological classification, genetic profile and clinical and prognostic features...

ea0092op-03-05 | Oral Session 3: Signalling in Thyroid cancer | ETA2023

From nucleus to mitochondria: insights into the role of tert in aggressive papillary thyroid carcinomas

Pogliaghi Gabriele , Muzza Marina , Grassi Elisa , Persani Luca , Fugazzola Laura

TERT is the protein component of the telomerase enzyme and is overexpressed in many cancer types. The most well-known role for TERT is the regeneration of telomeres allowing the avoidance of senescence and the continued proliferation of stem and cancer cells. Recent studies have identified other roles for TERT in compartments outside the nucleus, in particular in mitochondria, with a protective role against endogenous and therapy-induced oxidative stress (OS). A small subset o...

ea0070aep882 | Thyroid | ECE2020

In vitro modeling of thyroid cancer cells and fibroblasts interplay

Stellaria Grassi Elisa , Ghiandai Viola , Pogliaghi Gabriele , Fugazzola Laura , Persani Luca

Thyroid cancer (TC) is the most common endocrine tumor and its incidence has increased faster than in any other malignancy. Although TCs are usually well differentiated, disease recurrence or persistence is high, because of local and distant metastasis and therapeutic resistance. Among the different genetic alterations, BRAFV600E is the most frequent one. Several studies tried to establish a correlation between BRAFV600E and patients outcome, with controversial results. Nevert...

ea0081p217 | Thyroid | ECE2022

A combining pre-surgical thyroid risk score (TRS) for nodules with indeterminate cytology

Colombo Carla , Vannucchi Guia , Muzza Marina , Pogliaghi Gabriele , Palazzo Sonia , Dionigi Gianlorenzo , Persani Luca , Gazzano Giacomo , Fugazzola Laura

Background: Cytology is the gold standard method for the differential diagnosis of thyroid nodules, though 25−30% of them are classified as indeterminate and, in some cases, surgery is required for a definitive diagnosis. Aim: In order to reduce unnecessary thyroid surgeries, we set up a ‘thyroid risk score’ (TRS) to increase the diagnostic accuracy in a large series of patients with indeterminate cytology and to apply it to a validation ...

ea0084ps2-09-83 | Thyroid Hormone ACTION | ETA2022

FAM83B is involved in thyroid cancer cell differentiation and migration

Cirello Valentina , Stellaria Grassi Elisa , Pogliaghi Gabriele , Ghiandai Viola , Ermellino Laura , Muzza Marina , Gazzano Giacomo , Persani Luca , Colombo Carla , Fugazzola Laura

FAM83B has been recently identified as an oncogene involved in the development and progression of several malignancies, but its role in thyroid cancers (TC) is still unclear. In the present study, we examined the expression of FAM83B and its possible involvement in cell migration and differentiation, in neoplastic and normal thyroid tissues and in TC human cell lines. We found that FAM83B expression in TC varies according to tumor histotype, being si...

ea0099p576 | Thyroid | ECE2024

Radiofrequency ablation is an effective treatment for bethesda iii nodules without genetic alterations

Fugazzola Laura , Deandrea Maurilio , Borgato Stefano , Dell'Acqua Marco , Retta Francesca , Mormile Alberto , Carzaniga Chiara , Gazzano Giacomo , Pogliaghi Gabriele , Muzza Marina , Persani Luca

Radiofrequency ablation (RFA) is effective in the treatment of thyroid nodules, leading to a 50-90% reduction with respect to baseline. Current guidelines indicate the need for a benign cytology prior to RFA, though, on the other side, this procedure is also successfully used for the treatment of papillary microcarcinomas. No specific indications are available for nodules with an indeterminate cytology (Bethesda III and IV). Aim of the present study was to evaluate the efficac...