Searchable abstracts of presentations at key conferences in endocrinology

ea0026p340 | Obesity | ECE2011

Long term low intensity recreational physical exercise attenuates colonic inflammation in rats: the role of heme oxygenase system

Szalai Z , Berko A M , Posa A , Szabo R , Orban K , Kiraly A , Laszlo F , Varga Cs

Introduction: Obesity caused health problems are increasing. Metabolic syndrome including obesity with insulin resistance, hypertension, and high blood lipid levels increases the risks of cardiovascular and inflammatory diseases. Many studies have reported that heme oxygenase (HO) inducers reduce insulin resistance and severity of inflammatory bowel disease. We investigate the anti-inflammatory effect, one among many positive effects, of regular recreational physical activity ...

ea0026p581 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Long term recreational physical exercise decreases angina susceptibility and induces cardiovascular protective shifts in nitric oxide synthase, heme oxygenase and matrix metalloproteinase enzyme regulation in rats

Szabo R , Posa A , Szalai Z , Szablics P , Varga C S , Berko A M , Orban K , Laszlo F

Introduction: Physical inactivity, i.e. sedentary life style increases circulatory disease risk. Carbon monoxide and nitric oxide produced by the heme oxygenase (HO) and by the constitutive nitric oxide synthase (cNOS) protect circulation. In contrast, the enhanced level of the matrix metalloproteinase (MMP) augments cardiovascular risks. We examined the actions of recreational physical exercise on the expression of these enzyme systems in conjunction with cardiovascular prote...

ea0026p582 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Heme-oxigenase mediates cardiovascular protection by oestrogen and raloxifene in menopause

Posa A , Varga C S , Berko A M , Veszelka M , Szabo R , Orban K , Pavo I , Laszlo F

Introduction: Selective oestrogen receptor modulators function as oestrogen receptor antagonist in the breast and gonads, while they have agonistic effects on the bone and the cardiovascular system. It is also known that endogenously produced carbon monoxide by the heme-oxigenase (HO) enzyme exerts beneficial actions in cardiovascular protection.Design: Intact females, ovariectomized (OVX), raloxifene or oestrogen treated OVX Wistar rats were used. We st...

ea0022p168 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme-oxigenase synthase

Posa Aniko , Szablics Peter , Vari Beata , Szalai Zita , Kiss Gyongyi Karcsune , Varga Csaba , Laszlo Ferenc

In the reproductive age, it is well-known that males are more sensitive to cardiovascular ischemic disease than females. In our study, we investigated the role of heme-oxigenase synthase (HO), which produce endogenous vascular protective carbon monoxide, in the development of sexual dimorphism in rats. We found that HO synthase enzyme activity, and the expression its HO-1 and HO-2 isoenzyme were increased in female rat aorta and left heart ventricle compared to males. Moreover...