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ea0016p331 | Endocrine tumours | ECE2008

Novel MEN1 germline mutations and clinical features in Greek patients with multiple endocrine neoplasia type 1

Peppa Melpomeni , Pikounis Vasilios , Kamakari Smaragda , Peros George , Economopoulos Theofanis , Raptis Sotirios A , Hadjidakis Dimitrios

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder, associated with mutations of the MEN1 gene, characterised by the combined occurrence of tumours of the parathyroid glands, the pancreatic islet cells and the anterior pituitary.Aim: To identify MEN1 gene mutations and characterize clinical manifestations in Greek patients with MEN1.Patients and methods: We studied 4 ...

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ea0016p800 | Thyroid | ECE2008

Insulin resistance and oxidative stress induce advanced glycation end products formation in patients with clinical and subclinical hypothyroidism

Peppa Melpomeni , Hadjidakis Dimitrios , Alevizaki Maria , Dimitriadis George , Isari Georgia , Economopoulos Theofanis , Uribarri Jaime , Vlassara Helen , Raptis Sotirios A

Introduction: Advanced glycation end products (AGEs) formation is accelerated in various pathological conditions characterized by insulin resistance (IR) and/or increased oxidative stress (OS). Hypothyroidism overt (OH) or subclinical (SUH) is associated with a variety of metabolic disorders leading to IR and increased OS.Aim: To estimate the εN-carboxymethyl-lysine (CML) levels, in subjects with OH and SUH and seek f...

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Endocrine Abstracts

Novel MEN1 germline mutations and clinical features in Greek patients with multiple endocrine neoplasia type 1

Insulin resistance and oxidative stress induce advanced glycation end products formation in patients with clinical and subclinical hypothyroidism

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