Searchable abstracts of presentations at key conferences in endocrinology

ea0065in2.1 | Big data in space and time | SFEBES2019

Single cell technologies in endocrine systems

Rizzoti Karine

Single cell (sc) technologies offer an unprecedented level of investigation into cellular heterogeneity. Transcriptomic analyses are most commonly performed, but genome and epigenome can also be investigated at the sc level. Moreover, multi-omics technologies are developed to profile simultaneously different material from the same cell, enabling for example correlations between genomic mutations and alteration of gene expression. In parallel, spatial transcriptomics aim to com...

ea0020s17.2 | Stem cells niches in the endocrine system | ECE2009

A population of progenitor/stem cells in the adult pituitary

Rizzoti Karine

Tissue-specific progenitors play essential roles for organ development and homeostasis but they are not present in all tissues. Throughout life, the pituitary gland adapts the proportion of its endocrine cell types to meet hormonal demands. This plasticity may rely on adult progenitor cells and we have recently described such a population. These cells express SOX2, an HMG box transcription factor, marker of several embryonic progenitors and stem cells, and form ‘pituisphe...

ea0056mtbs2 | (1) | ECE2018

Single-cell technologies in development and disease with a special emphasis on endocrine systems

Rizzoti Karine

Recently developed single cell technologies offer unprecedented investigations of cellular heterogeneity. While significant hurdles remain to be overcome, the field is progressing rapidly. In addition to now commonly performed genome and transcriptome analysis, it appears possible to examine the epigenome, proteome and metabolome at the single cell level. In addition, multi-omics technologies are being developed to profile simultaneously different material sources from the sam...

ea0065oc2.2 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Investigating the role of AIP in pituitary tumourigenesis

Mistry Anisha , Solomou Antonia , Vignola Maria Lillina , Lim Chung Thong , Herincs Maria , Caimari Francisca , Costa Alejandro Ibanez , Begalli Federica , Gualtieri Angelica , Roncaroli Federico , Rizzoti Karine , Gaston-Massuet Carles , Korbonits Marta

Introduction: Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to growth hormone (GH, 90% of patients) or prolactin (PRL)-secreting tumours, with negligible number of patients with other pituitary tumour types. Animal models of acromegaly are scarce and Aip models have controversial data. Therefore we have generated two pituitary-specific Aip knockout mouse models to study the consequences of loss of AIP p...