Endocrine Abstracts

Single cell (sc) technologies offer an unprecedented level of investigation into cellular heterogeneity. Transcriptomic analyses are most commonly performed, but genome and epigenome can also be investigated at the sc level. Moreover, multi-omics technologies are developed to profile simultaneously different material from the same cell, enabling for example correlations between genomic mutations and alteration of gene expression. In parallel, spatial transcriptomics aim to com...

Tissue-specific progenitors play essential roles for organ development and homeostasis but they are not present in all tissues. Throughout life, the pituitary gland adapts the proportion of its endocrine cell types to meet hormonal demands. This plasticity may rely on adult progenitor cells and we have recently described such a population. These cells express SOX2, an HMG box transcription factor, marker of several embryonic progenitors and stem cells, and form ‘pituisphe...

Recently developed single cell technologies offer unprecedented investigations of cellular heterogeneity. While significant hurdles remain to be overcome, the field is progressing rapidly. In addition to now commonly performed genome and transcriptome analysis, it appears possible to examine the epigenome, proteome and metabolome at the single cell level. In addition, multi-omics technologies are being developed to profile simultaneously different material sources from the sam...

SOX9-positive pituitary stem cells differ according to their position in the gland and maintenance of their progeny depends on context. We and others have previously characterised a population of adult stem cells (SCs) in the murine pituitary gland. We showed that while these SCs are relatively quiescent in normal conditions, they undergo activation following target organ ablation, providing a well-characterized paradigm to study an adaptative response in the context of the en...

Introduction: Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to growth hormone (GH, 90% of patients) or prolactin (PRL)-secreting tumours, with negligible number of patients with other pituitary tumour types. Animal models of acromegaly are scarce and Aip models have controversial data. Therefore we have generated two pituitary-specific Aip knockout mouse models to study the consequences of loss of AIP p...