Searchable abstracts of presentations at key conferences in endocrinology

ea0021p65 | Clinical practice/governance and case reports | SFEBES2009

A rare case of isolated Cushing's disease from an ACTH and GH staining pituitary adenoma

Ahluwalia Rupa , Vora Jiten

A 31-year-old female presented with menstrual irregularities, weight gain and hirsutism.She was recently diagnosed with type 2 diabetes requiring Metformin therapy.Investigations: Serum cortisol levels failed to suppress on overnight dexamethasone suppression test (ODST) and low dose dexamethasone suppression tests (LDDST) (ODST: unsuppressed cortisol at 343 nmol/l, LDDST 48 h post dexamethasone cortisol of 397 nmol/l). The serum c...

ea0059ep90 | Reproduction | SFEBES2018

A rare case of primary hypogonadism and partial hypopituitarism in klinefelter syndrome

Rehman Shoib Ur , Ahluwalia Rupa

Klinefelter syndrome is the most common genetic cause of primary hypogonadism in men. Upto 80% have karyotype 47 XXY. It can present with a wide range of phenotypical and biochemical abnormalities. It is also known to be associated with certain autoimmune diseases. We describe a rare case of Klinefelter syndrome with partial hypopituitarism and suggest screening with full pituitary profile plus dynamics tests at first presentation if clinical suspicion is high. A 36 year old m...

ea0082wc5 | Workshop C: Disorders of the thyroid gland | SFEEU2022

Two case reports of suspected thyroid assay interference

Miler Emma , Chipchase Allison , Ahluwalia Rupa

Case 1: A 17-year-old female was referred to the endocrinology outpatients due to abnormal thyroid function tests (TFTs) (as below) detected on routine monitoring for Thyroxine replacement therapy. Following exclusion of pregnancy, possibilities of assay interference due to heterophilic antibodies as well as thyroid hormone resistance were considered. Repeat analysis was arranged at two laboratories using different methods. Results were concordant, excluding assay interference...

ea0062we4 | Workshop E: Disorders of the gonads | EU2019

Hypogonadotropic hypogonadism in a young woman undertaking intense exercise

MacFarlane James , Gaur Smriti , Ahluwalia Rupa

Background: Functional hypothalamic amenorrhoea (FHA) is a common cause of secondary amenorrhoea and is related to a combination of weight-loss, exercise and psychological stressors. These factors lead to suppression of pulsatile GnRH secretion. Diminished LH and FSH concentrations result in a hypoestrogenic state. We present an archetypal case of FHA that clearly demonstrates the ‘hypothalamic set-point’ for the body composition of a young woman below which...

ea0038p448 | Thyroid | SFEBES2015

Management of amiodarone induced thyrotoxicosis within the United Kingdom: is it time for a consensus guideline? A single centre retrospective review

Tisdale Mie Mie , Swords Francesca , Ahluwalia Rupa

Introduction: Amiodarone induced thyrotoxicosis (AIT) remains a diagnostic and therapeutic challenge. Broadly, AIT is classified as type 1 (underlying latent thyroid disorder) or type 2 (destructive thyroiditis). Despite being an on-going clinical conundrum, there is no U.K. wide guidance on management of AIT. We report a retrospective review of recent cases treated within our department as AIT.Methods: Data was collected for all patients referred to our...

ea0021p104 | Clinical practice/governance and case reports | SFEBES2009

A case of Verner-Morrison syndrome with solitary VIPoma and an incidental serous mucinous adenoma

Ahluwalia Rupa , Mon Aung , Vora Jiten

Introduction: Neuroendocrine tumors (NET) are very rare and often present a diagnostic challenge. They are often misdiagnosed due to non-specific symptoms. We report a rare case of NET presenting to a non endocrine unit.Case: A 72-year-old Caucasian female was referred for refractory diarrhoea with hypokalaemia. In addition, there was history of significant weight loss over few months.She had past medical history of diabetes, hyper...

ea0086p245 | Neuroendocrinology and Pituitary | SFEBES2022

An investigation into discrepancies between serum insulin-like growth factor 1 (IGF-1) concentrations and clinical presentation in the assessment of acromegaly

Miler Emma , McMurray Susanne , McArdle Nicholas , Ahluwalia Rupa , Chipchase Allison

Background: The suitability of serum insulin-like growth factor 1 (IGF-1) reference ranges (RR) used locally (manufacturer-derived), were raised as a clinical concern. IGF-1 levels above the RR were reported in patients displaying no clinical signs or symptoms of acromegaly, and in whom growth hormone suppression tests were negative. No analytical issue was evident, and quality performance indicators were satisfactory.Methods: A review of all serum IGF-1...

ea0065p25 | Adrenal and Cardiovascular | SFEBES2019

A case of severe hypokalaemia and metabolic acidosis

Gaur Smriti , Gunda Rohini , Ahluwalia Rupa , Todd Matt

Introduction: Hypokalaemia is a common biochemical abnormality seen in inpatients; it is usually mild and iatrogenic. We report a rare case of muscle paralysis due to severe unprovoked hypokalaemia, presenting on acute medical take.Case: The patient presented with a two week history of epigastric pain, nausea, vomiting, muscle spasms and dizziness. Past medical history included asthma, vitiligo, pernicious anaemia as well as long standing history of unex...

ea0034p313 | Pituitary | SFEBES2014

Optochiasmal cavernoma presenting with secondary hypogonadism: a case report

Ahluwalia Rupa , Khan Muhammad , Das Kumar , Sinha Ajay , Vora Jiten

Background: We report a case of a 35-year-old male presenting with pituitary dysfunction secondary to an optochiasmal cavernoma.The gentleman was initially referred with gynaecomastia and biochemical tests consistent with secondary hypogonadism. On further questioning he also reported extremely lethargy, difficulties with weight loss and poor libido. Examination was consistent with features of hypogonadism with reduced body hair, bilateral gynaecomastia ...

ea0034p339 | Reproduction | SFEBES2014

Hyperandrogenism secondary to ovarian hyperthecosis masked by concurrent use of an aromatase inhibitor: a case report

Khan Muhammad , Ahluwalia Rupa , Shore Susannah , Waghorn Alison , Vora Jiten

Backgound: We report a case of a 63-year-old postmenopausal female diagnosed with ovarian hyperthecosis masked by concurrent use of an aromatase inhibitor.Following diagnosis of breast cancer in 2009, requiring mastectomy with adjunctive chemotherapy, she was commenced on anastrozole. Later she noted gradual onset of frontal balding and hirsutism. Biochemistry revealed elevated serum levels of testosterone 13.2 nmol/l (range: <1.9 nmol/l) and androst...