Searchable abstracts of presentations at key conferences in endocrinology

ea0035p372 | Diabetes (epidemiology, pathophysiology) | ECE2014

Branched-chain and aromatic amino acid plasma concentration as a markers of metabolic syndrome

Daroszewski Jacek , Rybka Jacek , Pukajlo Katarzyna , Bolanowski Marek , Stankiewicz-Olczyk Joanna , Mierzchala Magdalena , Rybka Wojciech , Gamian Andrzej

Results of metabolomic studies showed the relation of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) with metabolic disorders.Basing on this observation we assessed amino acid profile in 286 professionally active men (aged 36–60 years). 141 of them met the criteria of metabolic syndrome (MS) and remaining 142 served as controls.Quantitative analysis of BCAA (leucine-LEU, valine-VAL, isoleucine- ILE) and AAA (...

ea0081rc1.3 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2022

Plasma amino acid profile in women with polycystic ovary syndrome and its correlation with metabolic disturbances

Paczkowska Katarzyna , Rachon Dominik , Berg Andrzej , Siomkajlo Marta , Rybka Jacek , Kapczynska Katarzyna , Bolanowski Marek , Daroszewski Jacek

Background: Polycystic ovary syndrome (PCOS) is a heterogenous endocrinopathy commonly diagnosed in reproductive age women, predisposing to the development of metabolic disturbances. However, the mechanisms underlying the connection between PCOS and metabolic disorders are still not well understood. The aim of the study was to investigate amino acid (AA) profile in women with PCOS and to assess its relation with metabolic disturbances.Methods: 326 women:...

ea0049gp72 | Diabetes & complications 1 | ECE2017

Specific plasma amino acids alternations associated with metabolic syndrome

Siomkajło Marta , Rybka Jacek , Gamian Andrzej , Stankiewicz-Olczyk Joanna , Bolanowski Marek , Daroszewski Jacek

Objectives: Amino acids (AA) plasma profile is associated with cardiometabolic diseases (CMD), predicts diabetes mellitus type 2 (DM2) and cardiovascular diseases (CVD) many years in advance. Metabolic syndrome (MS) defines the area of metabolic disturbances that precede DM2 and CVD development. The primary objective of the study was to examine the association between BCAA (branched chain amino acids), AAA (aromatic amino acids) profile and MS’s phenotype and to evaluate ...

ea0090p723 | Reproductive and Developmental Endocrinology | ECE2023

Early markers of metabolic disorders, such as leucin and isoleucine level and lipid accumulation product, should be considered as the potential additional criterium in PCOS classification

Paczkowska Katarzyna , Rachoń Dominik , Berg Andrzej , Rybka Jacek , Kapczyńska Katarzyna , Bolanowski Marek , Daroszewski Jacek

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...