Searchable abstracts of presentations at key conferences in endocrinology

ea0013p159 | Diabetes, metabolism and cardiovascular | SFEBES2007

The interactions between insulin and tumour necrosis factor-alpha in human aortic endothelial cells

Ritchie Stuart , Connell John , Salt Ian

There is a significant body of research that demonstrates an association between central (visceral) obesity, insulin resistance, endothelial dysfunction and accelerated atherosclerosis, but the molecular mechanisms underlying this link are incompletely understood. In cultured human aortic endothelial cell (HAEC) models, insulin stimulates an intracellular signalling cascade resulting in activating phosphorylation of Insulin Receptor Substrate-1, Protein kinase B (PKB/Akt) and ...

ea0038p200 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2015

AMPK activators modulate pro-inflammatory responses in human adipocytes

White Anna , Mancini Sarah , Nguyen Dinh Cat Aurelie , Montezano Augusto , Salt Ian , Touyz Rhian

Adipose tissue inflammation may be an important mechanism in the development of systemic insulin resistance, such that modulation of this system may be a therapeutic target for type 2 diabetes and obesity-related disorders. AMPK has anti-inflammatory properties, yet the anti-inflammatory actions of AMPK in adipocytes remain poorly characterised. We questioned whether AMPK activation influences pro-inflammatory responses in cultured adipocytes in basal and stimulated conditions...

ea0037oc5.3 | Steroids, developmental and paediatric endocrinology | ECE2015

Activators of AMP-activated protein kinase regulate adipocyte aldosterone secretion and mineralocorticoid receptor signalling

White Anna , Cat Aurelie Nguyen Dinh , Montezano Augusto , Salt Ian , Touyz Rhian

The increasing global prevalence of obesity requires urgent intervention to limit the anticipated surge of associated cardiometabolic morbidity and mortality. The energy sensor AMP-activated protein kinase (AMPK) is one proposed target for treating metabolic disorders and is downregulated in adipose tissue of obese insulin resistant individuals. Given the strong relationship between metabolic syndrome and overactivity of the renin-angiotensin-aldosterone system (RAAS) we inves...