Endocrine Abstracts

A 64 year-old Caucasian woman was admitted with a five-week history of lethargy, sore throat and dyspnoea, and diarrhoea with intermittent rectal bleeding, with a collapse on the morning of admission. She presented to the Emergency Department via ambulance and was found to be profoundly unwell with cold sepsis. She had a background of rheumatoid arthritis treated with weekly methotrexate, with no history of diabetes or long-term steroid-use. Blood tests revealed pancytopaenia,...

Background: Type 2 diabetes mellitus (DM) is probably one of the non-communicable diseases with raised levels of glucose in the blood due to insulin efficacy. The aetiology of disease combines both genetic and lifestyle or environmental factors. (GWAS) studies have been identified CAPN10 (SNP-19), FTO (rs-9939609), MTHFR (rs1801133) and PPARG (rs1801282) genetic polymorphism with susceptibility to T2DM. The susceptibility will increase by independent risk of genetic polymorphi...

Post-bariatric-surgery hypoglycaemia (PBH) typically presents at least six months post-operatively, particularly in those who have undergone Roux-en-Y gastric bypass (RYGB), with the literature suggesting that this condition develops in up to 30% of people post-bypass surgery. PBH is characterised by high postprandial insulin and glucagon-like peptide-1 secretion leading to hypoglycaemia 1-3 hours after consumption of meals that are high in carbohydrate content. We present the...

Objective: To compare FreeStyle Libre Glucose management indicator (GMI) with HbA1c and fructosamine and assess factors related to the difference.Methods: Persons with type 1 diabetes on FreeStyle Libre from a single diabetes centre whose sensor was active >70% of the time were included. Baseline characteristics, latest HbA1c, fructosamine, full blood count, total protein and albumin were collected from medical records. Ambulatory glucose profile dat...

BACKGROUND: Primary hyperparathyroidism (HPT) is increasingly diagnosed, particularly in an older population. Recent studies indicate improvement in bone mineral density (BMD) and psychological wellbeing even following treatment of apparent asymptomatic disease, supporting a lower threshold for surgical intervention. With disease being due to a solitary adenoma in most (83%) cases, we have utilised preoperative imaging together with intra-operative parathyroid hormone (IOPTH) ...