Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep700 | Pituitary and Neuroendocrinology | ECE2022

A Delphi panel of Italian endocrinologists to define the unmet needs on the current management of Cushing’s Syndrome

Pivonello Rosario , Carla Scaroni , Polistena Barbara , Migliore Antonio , Giustina Andrea

Introduction: Cushing’s Syndrome (CS) requires an accurate diagnosis, patient-tailored treatments and long-term management. To define the unmet needs of patients with CS, a consensus among a panel of Italian endocrinologists was promoted. The panel involved 57 specialists with expertise in CS management.Methods: The endocrinologists were identified by convenience sampling. The survey was built around a set of statements formulated after literature r...

ea0081p533 | Adrenal and Cardiovascular Endocrinology | ECE2022

Renin indicates the mineralocorticoid activity of fludrocortisone: a 6-year study in primary adrenal insufficiency

Ceccato Filippo , Torchio Marianna , Tizianel Irene , Barbot Mattia , Sabbadin Chiara , Betterle Corrado , Scaroni Carla

Context: Fludrocortisone (FC) is the mineralocorticoid (MC) replacement treatment for patients with primary adrenal insufficiency (PAI). Objective: To explore the dose of FC treatment and its relationship with glucocorticoid therapy, sodium, potassium, renin and clinical parameters. Design: Longitudinal study.Setting: Monocentric cohort.Patients: Data of 193 patients with PAI (130 autoi...

ea0081p658 | Pituitary and Neuroendocrinology | ECE2022

The diagnosis of recurrence during postoperative follow-up of Cushing’s disease

Barbot Mattia , Mondin Alessandro , Ceccato Filippo , Mazzeo Pierluigi , Lazzara Martina , Regazzo Daniela , Scaroni Carla

Introduction: Transsphenoidal surgery (TSS) is the first-choice treatment in Cushing’s disease (CD) with an immediate success rate of 70-80%. Unfortunately, due to the high rate of post-operative recurrences, CD patients require life-long surveillance. However, there is no consensus on how to follow these patients after TSS to early diagnose relapses. The aim of the study was to find reliable predictors of recurrence after neurosurgery in CD.Materia...

ea0063gp163 | Cushing's | ECE2019

Effects of a single dose of pasireotide on glucose metabolism in patients with Cushing’s disease and predictors of diabetes mellitus developement during treatment

Barbot Mattia , Regazzo Daniela , Zilio Marialuisa , Mondin Alessandro , Lizzul Laura , Pinelli Silvia , Scaroni Carla

Introduction: Pasireotide (PAS) is an effective treatment for Cushing’s disease (CD) but its use is burdened by the high incidence of diabetes mellitus (DM). We aimed to evaluate the effect of a single subcutaneous injection of PAS on glucose metabolism in CD patients, to identify factors predicting rapid deterioration of glycaemic control.Methods: 14 patients [(f/m=12/2, mean age 43±11.3 years, follow-up 17 months (2-63)] with CD treated with ...

ea0063gp192 | Adrenal and Neuroendocrine - Clinical | ECE2019

Diagnostic accuracy of captopril challenge test and saline infusion test in patients at high risk for primary aldosteronism

Ceccato Filippo , Barbot Mattia , Sabbadin Chiara , Lolli Jacopo , Antonelli Giorgia , Plebani Mario , Boscaro Marco , Scaroni Carla

Background and aim: Aldosterone-to-Renin Ratio (ARR) is recommended as initial test to screen for Primary Aldosteronism (PA), especially in high-risk hypertensive population. Endocrine Society (ES) Guidelines recommend that patients with an increased ARR should undergo one or more confirmatory tests in order to confirm or exclude PA diagnosis. Captopril Challenge Test (CCT) and Saline Infusion Test (SIT) are commonly used in routine clinical practice. The aim of our study was ...

ea0049ep1042 | Pituitary - Clinical | ECE2017

Autonomic impairment in idiopathic diabetes insipidus

Barbot Mattia , Ceccato Filippo , Zilio Marialuisa , Albiger Nora , Boscaro Marco , Bilora Franca , Scaroni Carla

Introduction: Since DI was reported to be associated to increase mortality, the aim of this study is to evaluate the presence of autonomic dysfunction (AD) in patients with DI.Methods: We enrolled 12 patients (six females) with central idiopathic DI and 12 controls, matched for age, sex and common cardiovascular risk factors, who were evaluated using the tilt, lying-to-standing, hand grip, deep breath, Valsalva maneuver and Stroop tests.<p class="abs...

ea0041ep859 | Pituitary - Basic | ECE2016

A C-terminal inhibitor of HSP90 decreases GH-promoter activity and growth hormone secretion in a cellular model of somatotrophinomas

Ciato Denis , Regazzo Daniela , Occhi Gianluca , Scaroni Carla , Stalla Gunter , Paez-Pereda Marcelo

Heat shock protein 90 (HSP90) plays a pivotal role in maturation and stabilization of proteins in conditions of stress. Many HSP90 client proteins are involved in oncogenic signaling and cancer progression, therefore HSP90 inhibitors have a potential as pharmaceutical agents. We reported a strong HSP90 overexpression in corticotroph adenomas and the treatment with C-terminal HSP90 inhibitors has potent anti-tumorigenic and anti-secretory effects in these tumors in vitro</e...

ea0037gp.21.01 | Pituitary – Diagnosis of Cushing's disease | ECE2015

A reappraisal of second line tests in the differential diagnosis of ACTH-dependent Cushing's syndrome: the role of three dynamic tests

Barbot Mattia , Trementino Laura , Ceccato Filippo , Zilio Marialuisa , Albiger Nora , Boscaro Marco , Arnaldi Giorgio , Scaroni Carla

Introduction: The diagnosis of Cushing’s syndrome (CS) might be challenging especially in ACTH-dependent CS when it comes to detect the origin of ACTH secretion.Materials and methods: We retrospectively recorded data about 170 patients with ACTH-dependent CS (149 CD, 21 EAS) referring to two Endocrinology Units. We focused especially on the performance of 3 dynamic tests: the dexamethasone 8 mg overnight challenging (HDDST), the CRH and the desmopre...

ea0070aep71 | Adrenal and Cardiovascular Endocrinology | ECE2020

Cardiovascular risk and metabolic profile in adult patients with congenital adrenal hyperplasia

Barbot Mattia , Ceccato Filippo , Patelli Ilaria , Regazzo Daniela , Lizzul Laura , Scaroni Carla

Background: Classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is characterized by impaired cortisol synthesis, requiring life-long glucocorticoid (GC) replacement therapy. Given the detrimental systemic effects of GCs in the long term, the aim of our study was to assess whether CAH patients have increased metabolic and cardiovascular alterations compared with age-matched controls.Materials and methods: For this cross-sectional...

ea0070aep695 | Pituitary and Neuroendocrinology | ECE2020

Markers of recurrence in cushing’s disease: The role of post-operative serum cortisol and desmopressin test

Barbot Mattia , Ceccato Filippo , Lizzul Laura , Mondin Alessandro , Regazzo Daniela , ZIlio Marialuisa , Scaroni Carla

Introduction: Transsphenoidal surgery (TSS) is the first-choice treatment in Cushing’s disease (CD). When performed by experienced neurosurgeon, post-operative remission can be achieved in 70–80% of cases; however, recurrences during follow-up are quite frequent, involving around 20–30% of patients initially in remission. Early detection of relapses is crucial to avoid cortisol-related comorbidities. The aim of the study was to find reliable predictors of rec...