Searchable abstracts of presentations at key conferences in endocrinology

ea0011s37 | Clinical lessons from novel aspects of G protein-coupled receptors signalling | ECE2006

Therapeutic implications from new aspects in V2 vasopressin receptor dysfunction

Schöneberg T

More than 190 disease-causing mutations of V2 vasopressin receptor (AVPR2) have been identified in patients with X-linked nephrogenic diabetes insipidus (NDI). About half of the mutations lead to a loss or truncation of the receptor protein whereas missense mutations present a variety of functional alterations such as reduced binding and signaling abilities and improper cell surface trafficking. To date, the therapy of NDI focuses mainly on treating clinical symptoms with thia...

ea0011s39 | Stromal cell-matrix interactions | ECE2006

Hormonal regulation of mesenchymal stem cell differentiation in bone

Jakob Franz , Seefried Lothar , Schütze Norbert , Ebert Regina

Mesenchymal Stem Cells (MSC) are the source of regeneration of musculoskeletal tissues. Stem cells (SC) are rare and slowly dividing cells, situated in stem cell niches, regulated by non-stem-cell cap cells. Rare symmetric SC division regulates the SC pool. Asymmetric cell division gives rise to a transient amplifying pool (MSCTAP). The MSC niche is poorly characterized in contrast to MSCTAP and consecutive events of fate decision, commitment and secretio...

ea0014p206 | (1) | ECE2007

Interaction of hypothalamic receptors involved in weight regulation

Rediger Anne , Tarnow Patrick , Grüters Annette , Schäfer Michael , Biebermann Heike

Objectives: Food intake is centrally regulated in hypothalamic nuclei where many G-protein-coupled receptors (GPCRs) are expressed which are known to be involved in weight regulation. Peripheral hormonal signals activate their corresponding receptors in the arcuate nucleus. Orexigenic signals activate POMC expression in one subset of neurons and inhibit AgRP and NPY expression in a second subset. Cleavage products of POMC, α- and β-MSH then stimulate melanocortin-4-r...

ea0011s75 | Green over-the-counter endocrinology | ECE2006

Regulation of steroid receptor expression and proliferation in prostate cancer by genistein and other flavonoids

Bektic J , Guggenberger R , Schäfer G , Bartsch G , Klocker H

A diet rich in phytoestrogens such as flavonoids has been attributed as one of the reasons for the low incidence of prostate cancer in Asia as opposed to Western countries with a diet rich in fat and meat and the highest incidences of this cancer. In many cellular models of prostate cancer these substances, the prototype of which is genistein, inhibit cell proliferation and cell cycle progression and enhance the rate of apoptosis. The molecular mechanisms involve modulation of...

ea0014p19 | (1) | ECE2007

Insulin decreases IGF-I bioactivity in patients with impaired glucose tolerance and in healthy subjects

Arafat Ayman M , Frystyk Jan , Weickert Martin O , Spranger Joachim , Schöfl Christof , Möhlig Mathias

Objectives: Insulin resistance (IR) is a very common metabolic abnormality in obesity, which is often associated with reduced growth hormone (GH) secretion. GH deficiency is associated with increased in intra-abdominal fat and several parameters of the metabolic syndrome. IGF-I improves IR but the IGF-binding proteins are supposed to regulate its bioactivity although only little information exists. We postulated that the elevated insulin levels due to IR do not only suppress G...

ea0014oc8.1 | Neuroendocrinology clinical | ECE2007

Growth hormone response during OGTT: the impact of assay method, gender and BMI on the estimation of reference values in patients with acromegaly and in healthy controls

Arafat Ayman M , Möhlig Mathias , Weickert Martin O , Perschel Frank H , Purschwitz Johannes , Spranger Joachim , Strasburger Christian J , Schöfl Christof , Pfeiffer Andreas FH

Objectives: Besides the measurement of IGF-1, GH suppression during OGTT to assess the biochemical status in acromegaly is recommended. However, as a consequence of the development of highly sensitive and specific GH assays a critical re-evaluation of the criteria for the diagnosis and follow-up management of acromegaly is mandatory. The aim of our study was to evaluate the between-method discrepancies in GH determinations by different immunoassays considering further confound...

ea0011p405 | Diabetes, metabolism and cardiovascular | ECE2006

Growth hormone and IGFBP-3 but not IGF-1 are independent predictors for insulin sensitivity in healthy subjects: on the role of hGH in the metabolic syndrome

Arafat MA , Perschel F , Schöfl C , Weickert M , Purschwitz J , Rochlitz H , Spranger J , Möhlig M , Pfeiffer AFH

Objectives: Insulin resistance (IR) and obesity are very common metabolic abnormalities, which are often associated with reduced GH secretion. GH reduces intraabdominal fat and its deficiency may contribute to the metabolic syndrome. IGF-1 improves IR but IGFBPs have a potential role in regulating its bioactivity although only little information exists. We postulate that the elevated insulin levels in IR may persistently suppress GH provided its regulation remains insulin sens...

ea0011p642 | Neuroendocrinology and behaviour | ECE2006

Glucagon-induced suppression of ghrelin secretion is exerted at hypothalamus-pituitary level and is not mediated by an increase in catecholamine secretion

Arafat MA , Perschel F , Otto B , Weickert M , Rochlitz H , Schöfl C , Spranger J , Möhlig M , Pfeiffer AFH

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. We showed earlier that glucagon induces a remarkable decrease in the orexigenic hormone: ghrelin. It was the aim of the present study to further evaluate the effect of glucagon on ghrelin secretion and the possible site of origin of this effect.Methods: We studied the endocrine and metabolic responses to intramuscular glucagon administration in 23 subjects (1...

ea0070aep596 | Pituitary and Neuroendocrinology | ECE2020

Efficacy and safety of long-acting pasireotide (LA-PAS) in patients with uncontrolled acromegaly: Results from the prospective cohort of european observational acronis study

Pivonello Rosario , Tabarin Antoine , Colao Annamaria , Kaltsas Gregory , Gonzalez-Molero Inmaculada , Neggers Sebastian , Venegas Moreno Eva , Kocjan Tomaz , Karges Wolfram , Krzyzanowska-Mittermayer Katarzyna , Heck Ansgar , Eden Engstrom Britt , Marques Ruben , O’Brien Eamonn , Manne Shobha , Vincenzi Beatrice , Schöfl Christof

Introduction: Results of the first European real-world evidence from retrospective cohort of ACRONIS study previously confirmed the efficacy and tolerability of LA-PAS in heavily pre-treated, uncontrolled acromegaly patients. Here, we report results of the second interim analysis reflecting the prospective cohort.Methods: Patients who were treated with LA-PAS for ≥6 months were included in this analysis. The primary objective was to document treatm...