Searchable abstracts of presentations at key conferences in endocrinology

ea0092ps3-23-05 | Pregnancy | ETA2023

Iodine nutritional status and related thyroid function in pregnancy: A results of a prospective study conducted in a large group of women

Sciarroni Elisabetta , Orsolini Francesca , Gianetti Elena , Montanelli Lucia , Bagattini Brunella , Fiore Emilio , Tonacchera Massimo

Background and Objectives: During pregnancy normal thyroid activity undergoes significant changes, including an increase in the amount of iodine intake and maternal renal iodine excretion. Hence, dietary iodine requirements are higher in pregnant women than in non-pregnant ones. This study aimed to assess the nutritional iodine status in a large group of pregnant women and thyroid function according to different iodine intake and thyroid diseases.Methods...

ea0084ps1-02-15 | Hypothyroidism | ETA2022

Use of iodine in the treatment of congenital hypothyroidism with an in situ thyroid gland and of non-autoimmune subclinical hypothyroidism

Pignata Luisa , Montanelli Lucia , Bagattini Brunella , Sciarroni Elisabetta , Agretti Patrizia , De Marco Giuseppina , Ferrarini Eleonora , Tonacchera Massimo , Di Cosmo Caterina

Introduction: Congenital hypothyroidism (CH) with in situ thyroid gland (GIS) and non-autoimmune subclinical hypothyroidism (NASI) are functional defects of thyroid gland occurring at birth and after birth, respectively. In recent years, a higher incidence of these disorders has been documented. The etiology remains unclear, with only an almost 50% of cases attributable to mutations in known dyshormonogenesis-associated or TSH-receptor genes. Although replacement ther...

ea0084ps1-02-16 | Hypothyroidism | ETA2022

Evolution of congenital hypothyroidism with in situ thyroid gland in children and adolescents: Clinical and biochemical features at diagnosis and after retesting

Bagattini Brunella , Agretti Patrizia , De Marco Giuseppina , Ferrarini Eleonora , Orsolini Francesca , Sciarroni Elisabetta , Tonacchera Massimo , Montanelli Lucia , Pignata Luisa

Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland (GIS) are identified. Outcome of children affected from CH with normally sited thyroid of normal size is still unknown. The objective of our study is to describe the natural history of this specific form of CH.Methods: We retrospectively evaluated clinical, biochemical and instrumental data of 89 patients with diagnosis of CH and GIS, refer...

ea0099p411 | Late-Breaking | ECE2024

Prevalence of hepatosteatosis in young women with polycystic ovary syndrome (PCOS)

Benetti Zaira , Buti Simona , Sciarroni Elisabetta , Pignata Luisa , Fiore Emilio , Salvati Antonio , Benelli Elena , Bagattini Brunella , Tonacchera Massimo

Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age, often characterized by obesity and insulin-resistance. NAFLD (Non-Alcoholic Fatty Liver Disease) is a metabolic disorder characterized by the accumulation of fat in the liver, in absence of alcohol consumption and other possible causes of hepatosteatosis. The association between hepatosteatosis and at least one cardio-metabolic risk factor is defined as MASLD (Metabolic Dysfunct...

ea0084ps1-02-14 | Hypothyroidism | ETA2022

A case of late-onset dyshormonogenic goiter with hypothyroidism due to a homozygous mutation of SLC26A7 gene

Sciarroni Elisabetta , Comi Simone , Montanelli Lucia , Latrofa Francesco , Brancatella Alessandro , Di Cosmo Caterina , De Marco Giuseppina , Ferrarini Eleonora , Pignata Luisa , Tonacchera Massimo , Agretti Patrizia

Introduction: Congenital hypothiroidism (CH) is the most common neonatal endocrine disorder, affecting up to one in 1500 to 2000 newborns, if mild forms of hypothyroidism with eutopic and normal-sized thyroid gland are included. It is caused by either dysgenesis or dyshormonogenesis. Recently a novel iodide transporter, SLC26A7 (a member of the SLC26 transporter family), whose dysfunction affects thyroid hormonogenesis in humans, has been identified. The main purpose of this s...

ea0092ps3-23-04 | Pregnancy | ETA2023

Physical development, neuropsychological health and quality of life in a group of adult subjects with congenital hypothyroidism early treated with levothyroxine after newborn screening

Pignata Luisa , De Marco Giuseppina , Ferrarini Eleonora , Agretti Patrizia , Di Cosmo Caterina , Bagattini Brunella , Sciarroni Elisabetta , Tonacchera Massimo , Bargagna Stefania , Montanelli Lucia

Background: The introduction of newborn screening for congenital hypothyroidism (CH) has led to prevent the most serious consequences of precocious deficit of thyroid hormone during child development, particularly neurological disability. However, little is known about long-term physical and psycho-social outcomes of CH after screening introduction.Objective: To evaluate physical and neuropsychological development and Quality of Life (QoL) in adult subje...