Endocrine Abstracts

Introduction: E2F1 regulates the expression of genes required for cell cycle progression and apoptosis. miR-17-5p regulates expression of E2F1. Both miR-17-5p and E2F1 have been described deregulated in cancer but they have been scarcely studied in human pituitary neuroendocrine tumours (PitNETs).The aim of the present study was to find biomarkers of aggressiveness in PitNETs and report the correlation between E2F1 and...

Gliomas are a common tumor type that affects the glial cells with common features of malignant tumors such as aggressive invasiveness, malignant transformation and vascular proliferation through the central nervous system. Currently, standard therapeutic strategies to treat malignant gliomas are not efficient having alow-rate survival (~12 months). Hence, there is a clear necessity for the identification of novel diagnostic/prognostic tools and therapeutic strategies to m...

Introduction: Gonadotroph tumours (GT) are the most common subtype of silent pituitary neuroendocrine tumours. The diagnosis of this subtype of tumours is established after surgery. There are no reliable markers of aggressiveness to predict their clinical course and, moreover, immunohistochemistry (IHC) usually classifies GT as null cell tumours. The aim of the present study was to correlate molecular, immunohistochemical and biochemical gonadotropin expression, to quantify th...