Endocrine Abstracts

Background: Thyroid storm is a rare but dangerous condition which can lead to multi-organ failure if not treated aggressively. Currently accepted treatment is with anti-thyroid medications to convert patients to a euthyroid state before definitive treatment with thyroidectomy is performed 10–14 days later. We present a case that was managed medically for several months due to a delay in surgery for clinical reasons. At present there are few such cases in the literature.</...

Introduction: Pseudo-Cushing’s syndromes are a heterogeneous group of disorders and include alcoholism, obesity, anorexia nervosa (AN), depression and intense physical exercise. These share biochemical features of Cushing’s syndrome (CS) causing ACTH-dependent hypercortisolism. Distorted body image is a prominent feature of eating disorders. We describe the case of patient with AN who was convinced she had CS. This led to investigations that confirmed hypercortisolis...

BACKGROUND: Atherosclerosis is a major cause of mortality in diabetes mellitus. Gene therapy may be a useful approach to the treatment of this disorder. One of the main obstacles to the use of this therapeutic modality is the difficulty in obtaining safe and efficient gene transfer in vivo. Adenoassociated virus vector have been used in a number of previous studies but have never been used for vascular gene delivery. OBJECTIVE: Our goal was to characterize AAV mediated gene de...

BACKGROUND: Atherosclerosis is a major cause of mortality in diabetes mellitus. Gene therapy may be a useful approach to the treatment of this disorder. One of the main obstacles to the use of this therapeutic modality is the difficulty in obtaining safe and efficient gene transfer in vivo. Adenoassociated virus vector have been used in a number of previous studies but have never been used for vascular gene delivery. OBJECTIVE: Our goal was to characterize AAV mediated gene de...

32 year old female presented to her GP following a first trimester miscarriage which consequently resulted in her experiencing secondary amenorrhoea for more than 9 months. Secondary amenorrhoea is defined as cessation of regular menses for 3-6 months or the cessation of irregular menses for 6-12 months. Her main concern was around her subfertility and dry skin. She started menarche at the age of 10 with regular monthly menses until her copper coil insertion 4 years ago. She h...

Angiogenesis is a crucial physiological phenomenon in female reproductive cycle. Our previous studies have shown that progesterone could inhibit proliferation of human umbilical vein endothelial cells (HUVEC) through a p53-dependent mechanism, by which the levels of p21 and p27 protein were increased, subsequently inhibiting the CDK2 kinase activity, and finally impaired the transition of the cell from the G1 phase to the S phase. While previous studies had clearly demonstrate...

Background: 17 α-hydroxylase enzyme deficiency is a rare condition and is responsible for < 1% of cases of congenital adrenal hyperplasia (CAH). Females present with delayed puberty due to reduced production of sex steroids and males can present with female external genitalia or with various degrees of genital ambiguity.Case presentation: A 4.5-year-old female – previously fit and well – presented to E...

The Hypoparathyroidism Symptom Diary (HypoPT-SD) was developed for the daily assessment of key symptoms and impact of HypoPT as reported by patients with chronic HypoPT and includes 13-items: a 7-item Symptom subscale, 4-item Impact subscale, and single-item anxiety and depression scores. The current analysis was undertaken to confirm test-retest reliability and construct validity of HypoPT SD Symptom subscale scores using data collected during two open-label, single-arm studi...

Background: People with Primary adrenal insufficiency (PAI) were identified as a vulnerable group by the UK government during the COVID-19 pandemic. Hence our aim was to evaluate the incidence of COVID-19, and associated adrenal crisis (AC) in people with PAI in the UK.Methods: A prospective observational study of patients with PAI was performed between January-June 2022. Participants were recruited via the Addison’s Disease Self Help Group. Diagnos...

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...