Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp94 | Diabetes therapy & complications 1 | ECE2017

The A allele of the -866G/A polymorphism in UCP2 gene decreases high glucose-induced UCP2 expression in HUVECs

Assmann Tais , Crispim Daisy , Rodrigues Michelle , Silva Liana , Boucas Ana Paula , Carlessi Rodrigo , Brondani Leticia , Canani Luis Henrique , Souza Bianca

Uncoupling protein 2 (UCP2) is a mitochondrial protein located in the mitochondrial inner membrane, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing reactive oxygen species (ROS) formation by mitochondrial respiratory chain. ROS overproduction is related to diabetic retinopathy (DR), a chronic complication of diabetes mellitus (DM). Recently, our group reported that the -866A/55Val/Ins haplot...

ea0063p155 | Diabetes, Obesity and Metabolism 1 | ECE2019

Improvement of human pancreatic islet quality after co-culture with human adipose-derived stem cells

de Souza Bianca , Rodrigues Michelle , de Oliveira Fernanda , da Silva Liana , Boucas Ana Paula , Portinho Ciro , dos Santos Bruno , Camassola Melissa , Martini Juliano , Leitao Cristiane , Nardi Nance , Bauer Andrea Carla , Crispim Daisy

Introduction: Pancreatic islet transplantation is an effective treatment for patients with type 1 diabetes mellitus (T1DM) with unstable metabolic control. However, the quality of islets isolated from a donor is negatively affected by the inflammatory environment related to the donor’s brain death and by the stress related to islet isolation and culture. To overcome islet quality loss, some studies have co-cultured islets with mesenchymal stromal cells (MSCs). Considering...