Endocrine Abstracts

Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing coronavirus disease (COVID-19), enters host cells via the angiotensin-converting enzyme 2 receptor. Its expression is higher in thyroid gland than in lungs. In the literature, an association between SARS-CoV-2 infection and subacute thyroiditis/autoimmune thyroid disease has been implicated. Therefore, we aimed to explore the influence of COVID-19 pandemic on the incidence of subacute th...

Background: During pregnancy, the immune system is suppressed. Therefore, autoimmune thyroid disorders (AITD) rarely appear in that period for the first time.Case report: We present a case of a 30-year-old female firstly referred to our department in the 25th week of pregnancy because of 14-day-lasting arterial hypertension. At the systolic blood pressure between 140 and 160 mmHg, her dyastolic blood pressure was between 60 and 70 mmHg. She had been norm...

Background: Thyroid nodule is the most common endocrine disorder with the prevalence of more than 50% in adults. Majority of nodules are small in size and can be detected only by various imaging methods. Thyroid nodules are usually benign, asymptomatic, and do not need treatment. Growing and large symptomatic thyroid nodules are usually treated with thyroidectomy. Novel minimally invasive ablation techniques can be alternative to surgery. Percutaneous laser ablation is causing...

Introduction: Resistance to thyroid hormone beta is a genetic disease defined by impaired sensitivity of target tissue to thyroid hormone caused by mutation of thyroid hormone receptor beta gene, appearing with an incidence of 1/40,000. The characteristic biochemical profile of resistance to thyroid hormone is elevated serum thyroid hormone level and inappropriate serum level of thyrotropin (TSH) which is normal or elevated. Clinical picture is variable ranging from asymptomat...

Objectives: Overt hyperthyroidism is reported to be associated with an increased mortality risk and an increased risk of cardiovascular (CV) complications such as an acute coronary syndrome requiring percutaneous coronary intervention, ischemic and non-ischemic stroke, atrial fibrillation and venous thromboembolism. Increased rate of acute CV events in the course of hyperthyroidism is well documented in Graves’ disease (GD) but not in subacute thyroiditis (ST). Last year ...

Introduction: The prevalence of thyroid nodules detected by ultrasound (US) is up to 50% in general population and approximately 5−10% of them is malignant. Diagnostic assessment includes laboratory tests thyroid US and thyroid scintigraphy, where suspicious nodules are characteristically cold when using99m Tc-pertechnetate as a tracer. A useful tool for US-based risk stratification of thyroid nodules is Thyroid Imaging Reporting and Data System (TIRADS). Rece...

Introduction: Radioiodine (I-131) therapy is an effective treatment for thyroid autonomy but may induce Graves’ disease (GD) but in up to 5% of patients. GD is characterised by antibodies against TSH receptor (TSHRAb). We set out to evaluate the incidence and risk factors of I-131-induced GD in patients with thyroid autonomy treated with I-131.Methods: We retrospectively reviewed patients with solitary toxic adenoma or toxic nodular goiter who were ...

Aim: In Graves’ disease (GD) the goal of radioiodine (I-131) application is the elimination of hyperthyroidism. The reported success rate 1 year after treatment is up to 90%. The aim of this retrospective study was to assess the factors influencing the early outcome 3 months after I-131 treatment of GD patients in an iodine sufficient area.Materials and Methods: We reviewed medical records of GD patients who received I-131 therapy between January 20...

Aim/Introduction: [18F]fluorocholine (FCH) positron emission tomography/computed tomography (PET/CT) has gained an important role in the preoperative diagnosis of patients with primary hyperparathyroidism (pPHP). In these patients, thyroid nodules are frequently found on preoperative ultrasound. FCH PET/CT provides a high negative predictive value to reliably rule out cancer in thyroid nodules with low uptake. However, more than half of benign thyroid nodules have b...