Searchable abstracts of presentations at key conferences in endocrinology

ea0051p015 | Gonadal, DSD and reproduction | BSPED2017

Consensus for UK principles of management of adolescents and infants with Disorders of Sex Development (DSD)

Matthews Rebecca , Crowne Elizabeth C , Skae Mars

Disorders of sex development (DSD) are a group of conditions caused by atypical development of chromosomal, gonadal or anatomical sex which pose complex, long-term diagnostic, investigative and management challenges requiring expert teams and close collaboration with families and peer groups. The lack of nationally agreed clinical standards for the management of DSD has been recognised by the British Society of Paediatric Endocrinology and Diabetes, and these are now in develo...

ea0085p77 | Obesity 2 | BSPED2022

Incidence and predictors of the complications of childhood obesity

Alder Rosie , Richardson Harriet , Fenwick Jonathan , Skae Mars , Chinoy Amish

Introduction: Paediatric obesity is associated with significant long-term complications. This study investigated features of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnoea (OSA) aiming to establish their incidence and identify any predictive factors.Methods: A retrospective review of case notes was performed for children aged 2-16 years managed for investigation and management of obesity within a single tertiar...

ea0066oc4.6 | Oral Communications 4 | BSPED2019

Understanding differences of sexual differentiation (DSD) MDT services across the UK; current service provision and sharing best practice

Eddy Danielle , Crowne Elizabeth , Alderson Julie , Skae Mars

Background: DSD services are evolving across the UK in response to both family, professional and societal pressures but MDT provision and access to specialist DSD services varies. In November 2017, DSD Clinical Standards were published by the BSPED Clinical Committee with the aim to improve and standardise DSD patient care and these were audited in March 2019. 95% of DSD centres responded with 85% listing psychology as part of their MDT.Aim: 1. To unders...

ea0045oc6.4 | Oral Communications 6- Endocrine | BSPED2016

Impact of intercurrent illness on calcium homeostasis and hypoparathyroidism management

Chinoy Amish , Mughal Zulf , Skae Mars , Babiker Amir , Padidela Raja

Introduction: Hypoparathyroidism is typically managed with calcitriol/alfacalcidol. Close monitoring of serum calcium is required as under-treatment causes symptomatic hypocalcaemia while over-treatment will cause nephrocalcinosis. We report three cases who demonstrated resistance to treatment during an intercurrent illness, necessitating increase in medication doses and monitoring.Case series: Case 1: Two-month-old boy with newly diagnosed hypo...

ea0095oc9.6 | Oral Communications 9 | BSPED2023

How does HbA1c compare with OGTT in identifying patients with Diabetes Mellitus and Pre-Diabetes

Sims Jack , Worth Chris , Manfredonia Claire , Ginbey Eleanor , Skae Mars

Introduction: The incidence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing within the paediatric community, prompting searches for a simple and effective screening tool. Oral glucose tolerance test (OGTT) is the gold standard but is poorly accessible in the community. HbA1c offers an alternative which can be easily performed, but cut-offs for children have been extrapolated directly from the adult American Diabetes Association (ADA) diagnostic criter...

ea0095p140 | Obesity 2 | BSPED2023

Evaluation of psychological and musculoskeletal outcomes in a tertiary weight management service at the Royal Manchester Children’s Hospital

Earnshaw Matthew , Skae Mars , Hughes Rhian , Tang Wing , Alim Salma

Background: Nearly a third of children aged 2–15 are overweight or obese (body mass index at or above 95th percentile) and children are becoming ‘obese’ at earlier ages and staying obese for longer. Obesity is linked to an array of medical conditions including hypertension, non-alcoholic fatty liver disease, and musculoskeletal pain and is associated with poor health-related quality of life (HRQoL) overall. Yet there is limited information on th...

ea0085oc9.6 | Oral Communications 9 | BSPED2022

A review of patient outcomes and responses to weight management strategies used by complications from excess weight service, a new paediatric, hospital-based weight management service

Lunat Zainab , Alim Salma , Mulligan Nicola , Joy Niamh , Tang Wing , Skae Mars

In June 2021, NHS England commissioned 15 Complications from Excess Weight (CEW) services to pilot Tier 3 paediatric weight management services in England. This study aimed to assess initial patient experiences / responses to weight management strategies delivered in a single CEW service between January-June 2022.Methodology: We conducted an online survey to assess patient experiences, motivators and barriers to healthy lifestyle change in 45 patients se...

ea0036P59 | (1) | BSPED2014

Is there a role for medical management in childhood obesity? A review of the Manchester Metabolic Obesity Service

Tan Sherie , Skae Mars , Banerjee Indi , Padidela Raja , Ehtisham Sarah , Mughal Zulf , Clayton Peter , Patel Leena

Background: Childhood obesity is a growing problem worldwide, with serious effects on child health. Obese children are at a higher risk of developing metabolic co-morbidities earlier in life (WHO, 2013). Manchester has worse than national average levels of obesity, with an estimated 14 000 obese children (PHE, 2014).Aims and methods: A retrospective case note analysis of 117 obese paediatric patients, seen in our service between March 2012 and 2014, was ...

ea0058oc6.3 | Oral Communications 6 | BSPED2018

Has the reduction in maintenance fluid rates following introduction of 2015 BSPED-recommended diabetic ketoacidosis guidelines impacted on complication rates?

Chinoy Amish , Doughty Ian , Bone Mark , Skae Mars , Murray Philip , Padidela Raja

Introduction: In August 2015, a revision of the BSPED-recommended guideline for the management of diabetic ketoacidosis (DKA) was published. A key difference from the previous guideline was a reduction in maintenance fluid rates, with the aim of reducing the incidence of cerebral oedema. Since implementation of these national guidelines, there have been reports within regional networks of an increased incidence in mild acute renal impairment and hypokalaemia. This retrospectiv...

ea0027p77 | (1) | BSPED2011

Octreotide treatment for congenital hyperinsulinism can cause hepatitis

Avatapalle Bindu , Rigby Lindsey , Patel Leena , Ehtisham Sarah , Skae Mars , Padidela Raja , Banerjee Indraneel , Clayton Peter

Introduction: Congenital hyperinsulinism (CHI) is a rare condition of dysregulated insulin secretion causing hypoglycaemia. Oral Diazoxide is used as first line therapy for CHI. In those who are Diazoxide unresponsive, subcutaneous Octreotide is used as second line treatment. Octreotide has recognised side effects of biliary stasis. Additionally, we report hepatitis as a complication of Octreotide therapy in a child with CHI.Case report: A neonate with C...