Endocrine Abstracts

Objective: Mortality in autoimmune Addison’s disease (AAD) is increased twofold compared to matched populations. Cardiovascular disease (CVD) is the most common cause of death, but little is known of cardiovascular morbidity. Inadequate glucocorticoid replacement has been implicated in the increased risk of CVD, but evidence is lacking. The objective of this study was to examine cardiovascular morbidity and mortality in AAD, and to investigate the effects of glucocorticoi...

Objective: Several autoimmune disorders are known to be associated with an increased risk of psychiatric morbidity. Yet, the effect of autoimmune Addison’s disease (AAD) on mental health is not well known. The aim of this study was to examine the use of psychotropic drugs around diagnosis in Swedish individuals with AAD.Design and methods: In this population-based cohort study, The Swedish national patient register, and the Swedish Addison register ...

Objective: Hyponatremia is associated with considerable morbidity, and mortality but causal links have been difficult to establish. Here, we describe the establishment and representativeness of the Stockholm Sodium Cohort (SSC), designed to study etiologies and outcomes of hyponatremia.Study, Design and Setting: All residents of Stockholm County, undertaking at least one serum sodium test between 2005-2018 were included in the SSC. Individual-level test ...

Background: Hashimoto´s thyroiditis (HT) and Graves´ disease (GD) are known co-aggregate in families, but the magnitude and nature of a shared etiology is unknown. The aim of this study was to estimate the shared genetic influence on these diseases. In addition, we sought to examine if the heritability of HT and GD differs between men and women.Methods: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swe...

Background: Previous studies have found reduced health-related quality of life and employability in patients with autoimmune Addison’s disease (AAD). However, there are no large studies examining the economic cost of illness for the individual.Objective: To study differences in income and work loss between patients with AAD and matched comparators.Methods: In this cross-sectional study we linked the Swedish Addison Register an...

Background: Current dogma states that in autoimmune Addison’s disease (AAD), all adrenocortical function eventually is lost. Yet growing evidence suggests that a subgroup of patients retain some self-production.Aim: To explore whether residual production of adrenocortical steroids is present in a subgroup of AAD patients.Material and methods: In an open non-randomized cross-sectional study, an interim of 22 AAD patients delive...

Background: Previous research show that autoimmune adrenal insufficiency develops gradually over time and inexorably results in a total inability to produce adrenal steroids. However, growing evidence suggest that a few patients preserve some steroid producing capacity.Aim: To explore the frequency of residual cortisol production and possible clinical consequences in patients with autoimmune Addison´s disease (AAD).Material an...

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addison’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...