Searchable abstracts of presentations at key conferences in endocrinology

ea0056oc10.1 | Cardiovascular aspects of endocrine diseases | ECE2018

Glucocorticoid replacement-doses and cardiovascular events in autoimmune Addison’s disease – a population based retrospective cohort study

Skov Jakob , Sundstrom Anders , Ludvigsson Jonas , Kampe Olle , Bensing Sophie

Objective: Mortality in autoimmune Addison’s disease (AAD) is increased twofold compared to matched populations. Cardiovascular disease (CVD) is the most common cause of death, but little is known of cardiovascular morbidity. Inadequate glucocorticoid replacement has been implicated in the increased risk of CVD, but evidence is lacking. The objective of this study was to examine cardiovascular morbidity and mortality in AAD, and to investigate the effects of glucocorticoi...

ea0099p216 | Adrenal and Cardiovascular Endocrinology | ECE2024

Psychotropic drugs in patients with Addison’s disease: A Swedish population-based cohort study

Oster Sara , Spelman Tim , Kampe Olle , Bensing Sophie , Skov Jakob

Objective: Several autoimmune disorders are known to be associated with an increased risk of psychiatric morbidity. Yet, the effect of autoimmune Addison’s disease (AAD) on mental health is not well known. The aim of this study was to examine the use of psychotropic drugs around diagnosis in Swedish individuals with AAD.Design and methods: In this population-based cohort study, The Swedish national patient register, and the Swedish Addison register ...

ea0099ep350 | Pituitary and Neuroendocrinology | ECE2024

Establishment and representativeness of the stockholm sodium cohort: a laboratorial and pharmacoepidemiologic database covering 1.6 million individuals in the stockholm county

Issa Issa , Mannheimer Buster , Franko Mikael , Skov Jakob , Lindh Jonatan , Falhammar Henrik

Objective: Hyponatremia is associated with considerable morbidity, and mortality but causal links have been difficult to establish. Here, we describe the establishment and representativeness of the Stockholm Sodium Cohort (SSC), designed to study etiologies and outcomes of hyponatremia.Study, Design and Setting: All residents of Stockholm County, undertaking at least one serum sodium test between 2005-2018 were included in the SSC. Individual-level test ...

ea0070aep1096 | Hot topics (including COVID-19) | ECE2020

Limited genetic overlap between Hashimoto´s thyroiditis and Graves´ disease in Swedish twins: A population-based study

Skov Jakob , Calissendorff Jan , Eriksson Daniel , Ludvigsson Jonas , Magnusson Patrik , Kämpe Olle , Bensing Sophie , Kuja-Halkola Ralf

Background: Hashimoto´s thyroiditis (HT) and Graves´ disease (GD) are known co-aggregate in families, but the magnitude and nature of a shared etiology is unknown. The aim of this study was to estimate the shared genetic influence on these diseases. In addition, we sought to examine if the heritability of HT and GD differs between men and women.Methods: We used national health registries to identify cases of HT and GD in a cohort of 110 814 Swe...

ea0099p425 | Adrenal and Cardiovascular Endocrinology | ECE2024

Income and work loss in patients with Addison’s disease in Sweden: A nationwide population-based study

Stergianos Stavros , Everhov Asa Hallqvist , Soderling Jonas , Bergthorsdottir Ragnhildur , Wahlberg Jeanette , Kampe Olle , Skov Jakob , Bensing Sophie

Background: Previous studies have found reduced health-related quality of life and employability in patients with autoimmune Addison’s disease (AAD). However, there are no large studies examining the economic cost of illness for the individual.Objective: To study differences in income and work loss between patients with AAD and matched comparators.Methods: In this cross-sectional study we linked the Swedish Addison Register an...

ea0063p431 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Residual adrenocortical function in autoimmune addison’s disease: interim results of a cross-sectional study

Saevik AEse Bjorvatn , AEkermann Anna-Karin , Methlie Paal , Gunnar Nedrebo Bjorn , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Holte Synnove Emblem , Debowska Aleksandra , Sollid Stina Therese , Jorgensen Anders , Nermone Ingrid , Gronning Kaja , Finnes Trine , Grimnes Guri , Hoybye Charlotte , Skov Jakob , Dahlqvist Per , Wahlberg Jeanette , Isaksson Magnus , Quinkler Marcus , Bensing Sophie , Oksnes Marianne , Husebye Eystein

Background: Current dogma states that in autoimmune Addison’s disease (AAD), all adrenocortical function eventually is lost. Yet growing evidence suggests that a subgroup of patients retain some self-production.Aim: To explore whether residual production of adrenocortical steroids is present in a subgroup of AAD patients.Material and methods: In an open non-randomized cross-sectional study, an interim of 22 AAD patients delive...

ea0070aep1 | Adrenal and Cardiovascular Endocrinology | ECE2020

Residual corticosteroid production in autoimmune addison´s disease

Bjorvatn Saevik Åse , Åkerman Anna-Karin , Methlie Paal , Quinkler Marcus , Palmström Jörgensen Anders , Höybye Charlotte , Debowska Aleksandra J , Gunnar Nedrebø Bjørn , Lise Dahle Anne , Carlsen Siri , Tomkowicz Aneta , Therese Sollid Stina , Nermoen Ingrid , Grønning Kaja , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna F , Wahlberg Jeanette , Emblem Holte Synnøve , Simunkova Katerina , Kämpe Olle , Sverre Husebye Eystein , Bensing Sophie , Øksnes Marianne

Background: Previous research show that autoimmune adrenal insufficiency develops gradually over time and inexorably results in a total inability to produce adrenal steroids. However, growing evidence suggest that a few patients preserve some steroid producing capacity.Aim: To explore the frequency of residual cortisol production and possible clinical consequences in patients with autoimmune Addison´s disease (AAD).Material an...

ea0073aep4 | Adrenal and Cardiovascular Endocrinology | ECE2021

Biomarkers of cardiovascular disease and inflammation in autoimmune addison’s disease with residual adrenocortical function

Åse Bjorvatn Sævik , Anna-Karin Åkerman , Methlie Paal , Quinkler Marcus , Anders Jørgensen , Charlotte Höybye , Debowska Aleksandra , Bjørn Gunnar Nedrebø , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Synnøve Holte , Sollid Stina Therese , Nermoen Ingrid , Kaja Grønning , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna , Wahlberg Jeanette , Simunkova Katerina , Olle Kämpe , Husebye Eystein Sverre , Bensing Sophie , Marianne Øksnes

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addison’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...