Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

Introduction: There continues to be much discussion around optimization of thyroid hormone status in hypothyroid individuals. The ideal therapeutic goal in hypothyroidism would be to restore clinical and biochemical euthyroidism via physiologic thyroid hormone replacement. This concept may seem straightforward, but there are subtleties that have only recently been recognized. We here looked the way that FT4 and TSH related to each other in a large laboratory sample of people w...

Introduction: Levothyroxine monotherapy is the standard treatment for hypothyroidism; it is safe and inexpensive, restores thyroid function tests to within the reference range, and improves symptoms in most patients. However, some patients require Liothyronine (LT3) to improve symptoms, and there is less safety data available for this. Here we report a case of sudden death in a patient using Liothyronine and present a safety data review for Liothyronine and Levothyroxine using...

Introduction: There continues to be much discussion around optimization of thyroid hormone status in hypothyroid individuals. We looked the way that FT4/TSH relate to each other in people who underwent a check of thyroid function (TFT) split between those on levothyroxine replacement (monitoring-test) and those who underwent TFT check as a screening test for thyroid hormone imbalance not-on-levothyroxine.Methods: TFT test (FT4/TSH) results were taken fro...

Context: Approximately 15% of people with hypothyroidism remain symptomatic despite treatment. The Thr92Ala substitution in DIO2, may influence T3 tissue levels.Methods: We assessed HADS anxiety and depression scores in HUNT2 in 50,901 individuals (6,687 homozygous for Thr92Ala) of whom 1,480 had a history of levothyroxine use (180 homozygous for Thr92Ala). Anxiety and depression caseness (score>=8) by levothyroxine and Thr92Ala status was a...

Context: Up to 15% of people with hypothyroidism remain symptomatic despite treatment with levothyroxine. A proportion of these utilise combination thyroid hormone replacement, T3 monotherapy and desiccated thyroid extract (DTE). We sought to explore thyroid hormone profiles in these patients.Methods: We performed hourly blood tests (8.30am-4.30pm) to assess TSH, T3 and T4 levels in 49 individuals (n =14 combination thyroid hormone replacement, ...

Context: Approximately 10% of patients on levothyroxine remain symptomatic despite restoration of biochemical euthyroidism. Some therefore utilise alternatives to levothyroxine monotherapy including combination thyroid hormone replacement, T3 monotherapy and desiccated thyroid extract (DTE). We examined thyroid hormone profiles in these patients.Methods: We examined 49 individuals 14 on combination thyroid hormone replac...

Introduction: Primary hypothyroidism affects about 3% of the general population in Europe. In most cases, people are treated with Levothyroxine. In relation to the recent British Thyroid Association guidance and the 2020 Competitions and Marketing Authority (CMA) ruling, we examined prescribing data for levothyroxine, NDT and liothyronine by dose, regarding changes from 2016 to 2022.Design: Monthly primary care prescribing data for each British National ...

Introduction: Microvascular and macrovascular complications in type 1 diabetes T1D) may be linked to endothelial stress due to glycaemic variability. This work aimed to examine whether determination of glycaemic parameters including glucose variability (GV) over an 18month period is associated with microvascular clinical sequelae. Methods: Freestyle Libre 15-minute glucose values were downloaded for 89 T1DM individuals for up to 18 months from 2021 to 20...