Searchable abstracts of presentations at key conferences in endocrinology

ea0010s10 | Non classical sites of action of classical hormones | SFE2005

Direct actions of pituitary hormones on bone

Zaidi M , Sun L , Onigata K , Abe E

We have revisited the actions of hormones from the anterior pituitary, notably TSH, on bone and bone cells. Traditionally, the bone loss in hyperthyroidism has been attributed solely to elevated circulating levels of thyroid hormones. The role of TSH, which is reduced in all forms of hyperthyroidism, as well as during thyroxine suppressive therapy for thyroid cancer, has never been investigated. We found that haploinsufficiency of the TSH receptor in mice led to bone loss with...

ea0029p762 | Endocrine Disruptors | ICEECE2012

The effects of BPA exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women.

Liu J. , Zhao H. , Bi Y. , Ma L. , Zhang L. , Zhao L. , Tao B. , Sun L. , Wang T. , Zhao Y. , Wang W. , Xu M. , Chen J. , Ning G.

Objective: Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. In the present study, we aimed to examine the complex interplay between BPA exposure, fat mass, fat-free mass, serum estradiol, leptin, osteocalcin levels and BMDs in a group of premenopausal women.Methods: A total of 246 Chinese premenopausal women aged 20 years and older with regular menstrual cycles were investigated...