Endocrine Abstracts

Case history: A 32 female was referred to a tertiary maternity unit due to hypercalcaemia and a diagnosis of primary hyperparathyroidism (PHPT). She had learning difficulties, 2 previous C-sections and was a smoker. She presented 5 years earlier to her local hospital with abdominal and leg pains, nausea, constipation and fatigue. She had undergone 2 parathyroidectomies but remained hypercalcaemic and had been managed medically with Cinacalcet when she conceived an unplanned pr...

The purpose of this study was to explore the use of testosterone treatment and patients’ knowledge in male hypogonadism. A questionnaire was sent to all 213 patients on testosterone replacement therapy recorded in our clinic database, with a response rate of 35.7% (n=76). Respondents’ age ranged from 19 to 87 years (mean=44.5; S.D.=16.2). Causes of hypogonadism for this group are presented in Table 1.<table boarder="1" cellpadding="3" cellsp...

Background: AdipoQ gene is located at the 3rd chromosome and encodes foradiponectin which is involved in fat metabolism and insulin sensitivity and plays a protective role in diabetes and atherogenesis. AdipoQgene variants have been reported to be associated with hypertriglyceridemia and risk of diabetes in different studies. We aimed to study whether polymorphism of rs2241766 polymorphic form of AdipoQ gene & its expression in adipose tissue is associated with post prandi...

Objective: To evaluate the outcome of fine needle aspiration biopsy (FNAB) of solid thyroid nodules, and the utility of thyroid ultrasound in determining the nature of solid nodules in our practice.Methods: We reviewed the diagnostic outcome of FNAB of solid thyroid nodules in 93 patients from our dedicated thyroid biopsy clinic. In addition we compared the predictive value of sonographic assessment with FNAB in a subset of patients who had undergone bot...

Introduction: Carbimazole is the first drug of choice for treating thyrotoxicosis. We report a case of an Asian gentleman recently started on carbimazole for thyrotoxicosis who complained of severe generalised muscle pain and weakness.Report: A sixty-four year old gentleman was diagnosed with thyrotoxicosis (TSH <0.01 mU/l, Free T4=40 pmol/l, Free T3=14.9 pmol/l) in the month of July 08 and was started on carbimazole 40 mg daily...

A 72 years old lady was referred to endocrine clinic with raised serum calcium of 2.69 mmol/l and PTH of 99.6 ng/l (3.0–48.0 ng/l) detected during investigations for an abnormal skeletal survey. She was known to have osteoporosis from the age of 59 diagnosed on Dexa scan. Case notes revealed raised serum calcium of 2.52–2.60 mmol/l since year 2000. Her repeat serum calcium was 2.77 mmol/l with phosphate of 1.03 mmol/l and 25 hydroxy vitamin D of 36 nmol/l. She admitt...

This 48-year-old with consanguineous parentage presented at the age of 23 in 1980 with congenital bilateral sensorineural deafness and hypothyroidism requiring replacement with 150 mcg thyroxine. There was a family history of deafness and thyroid disease. A perchlorate discharge test was performed and 42% of the radioiodine within the gland was discharged by potassium perchlorate (NR <10%).Over the following decade she developed a diffuse goitre whic...

Ion and fluid transport mechanisms within the eye are important for several key physiological processes including the maintenance of corneal transparency and the regulation of intraocular pressure (IOP). The mechanism involved in epithelial sodium transport in the eye is regulated by corticosteroids and at a pre-receptor level, by 11β-hydroxysteroid dehydrogenase (11β-HSD) activity. Recent studies localised type 1 (11β-HSD1), an oxo-reductase that activates cort...

Introduction: US Food and Drug Administration (FDA) has recently approved bexagliflozin, a new SGLT2 inhibitor. We examined the outcomes and metabolic effects of Bexagliflozin across the published Randomised Controlled Trials (RCCTs)Methods: A comprehensive literature search was done to extract publications from Medline-PubMed and Cochrane library, since inception till January 20, 2023, then screened and reviewed by two independent reviewers. Data includ...

Introduction: The morbidity of craniopharyngioma (CP) includes cognitive dysfunction with attention deficits, impaired episodic memory and processing speed (Fjalldal et al., 2013) and CP patients with hypothalamic damage are more affected. fMRI is a technique used to investigate cortical activity by detecting alterations in blood flow in response to stimuli or actions. Previously pre- and post-meal fMRI responses to visual food cues were investigated showing higher ac...