Searchable abstracts of presentations at key conferences in endocrinology

ea0019p194 | Endocrine tumours and neoplasia | SFEBES2009

Essential role of TRPC channels in human ovarian cancer cell proliferation

Wake J , Dickerson E , Avazzadeh S , Watson NM , Saurabh R , Atkin SL , Xu SZ

The transient receptor potential canonical channels (TRPC) are a new family of Ca2+-permeable cationic channels controlling the Ca2+ influx response to the activation of the G-protein coupled receptor or the depletion of the internal Ca2+ store, which is related to the cellular signalling mechanisms of many hormones or growth factors. The role of TRPC channels in cancer development is still unclear. Therefore, we aimed to investigate the expres...

ea0016p811 | Thyroid | ECE2008

Papillary thyroid microcarcinoma in 188 consecutive thyroidectomies

Bayo Juan Angel Hernandez , Sz.-Somoza Monica Belinchon , Monsalve Pablo , Viera Manuel Garcia

Objective: Papillary thyroid microcarcinoma (PTM) is a malignant thyroid tumor with potential multifocality and diameter ≤1 cm. This carcinoma has been discovered more frequently like incidentaloma, and the epidemiology is not clearly established. We have analysed epidemiologic and clinical characteristics in La Palma Island.Patients and methods: We collected all cases of PTM diagnosed in 188 consecutive thyroidectomies performed for whichever caus...

ea0014p529 | (1) | ECE2007

Non-NMDA glutamate receptor antagonist injected into the mesencephalic dorsal raphe nucleus inhibits the suckling-induced prolactin release and administered into the lateral cerebral ventricle interferes with the diurnal fluctuations of plasma prolactin of male rats

Bodnár Ibolya , Bánky Zsuzsanna , Halász Béla

We examined the functional significance of the glutamatergic innervation of the dorsal raphe nucleus (DR) in the mediation of the suckling stimulus inducing prolactin release. A non-NMDA (6-cyano-7-nitroquinoxaline-2,3-dione disodium, CNQX) or an NMDA glutamate receptor antagonist (dizocilpine hydrogen malate, MK-801) was injected into the DR of freely moving lactating rats at the end of 4 h separation. The litters were then returned and blood samples for prolactin were taken ...

ea0070aep730 | Pituitary and Neuroendocrinology | ECE2020

Global methylation-demethylation status in pituitary neuroendocrine tumors as potential therapeutic target

Szabó Borbála , Németh Kinga , Mészáros Katalin , Szücs Nikolette , Czirják Sándor , Reiniger Lilla , Patócs Attila , Butz Henriett

Background: The altered DNA methylation of certain genes in Pituitary Neuroendocrine Tumors (PitNETs) are well known. However little information is available regarding global methylation changes and the process of demethylation in these tumors. In addition, influencing global methylation-demethylation could be a potential new therapeutic option especially in clinically non-functional PitNETs.Material and Methods: Overall, 44 fresh frozen pituitary adenom...

ea0022p761 | Thyroid | ECE2010

Crescent incidence of papillary thyroid microcarcinoma: 2000--09

Bayo Juan A Hernandez , Belinchon Sz.-Somoza Monica , Bayo Jose M Hernandez , Criado Luis Acosta , Viera Manuel Garcia

Objective: Papillary thyroid microcarcinoma (PTM) is a malignant thyroid tumour with potential multifocality and diameter ≤1 cm. Usually is found like incidentaloma, and the epidemiology is not clearly established. We have analysed their epidemiologic in La Palma Island at last 10 years.Patients and methods: We collected all cases of PTM diagnosed in 345 consecutive thyroid surgeries performed for whichever benign thyroid disease (thyrogloss duct c...

ea0014p525 | (1) | ECE2007

Glutamatergic neurons and synaptic contacts between glutamatergic axon terminals and chemically identified nerve cells in the rat hypothalamic suprachiasmatic nucleus

Kiss József , Csaba Zsolt , Csáki Ágnes , Halász Béla

The hypothalamic suprachiasmatic nucleus (SCN) is the key-structure of the control of circadian rhythms. Several observations support the view that glutamate is the primary transmitter of the retinal projection to this cell group. The glutamatergic innervation of the nucleus is not limited to this projection, it is much more extended. The aim of our investigations was (1) to examine whether are glutamatergic neurons existing in the SCN and (2) to get information about the rela...

ea0070aep568 | Pituitary and Neuroendocrinology | ECE2020

Modelling neuroendocrine tumours using 3 dimensional cell culturing

Krokker Lilla , Szabó Borbála , Németh Kinga , Sarkadi Balázs , Mészáros Katalin , Patócs Attila , Butz Henriett

Introduction: In vitro monolayer cell cultures are not able to faithfully model the biological features of the three dimensional (3D) structure of solid tumours. There are limited information about the applicability of 3D cell culturing methods for modeling of tumours of endocrine organs.Aim: The aim of our work was the establishment and characterization of three-dimensional in vitro models of various endocrine tumour cells in order to ...

ea0014p100 | (1) | ECE2007

Inhibition of C17,20-lyase activity by new 17β-exo-heterocyclic androsterone derivatives

Szécsi Mihály , Tóth István , Wölfling János , Schneider Gyula , Julesz János

17α-Hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment of prostatic carcinoma, which is androgen-dependent in the majority of cases. Abiraterone and its analogues have been found strong inhibitors of P45017α suggesting that steroid de...

ea0014p593 | (1) | ECE2007

The effects of salsolinol on the peripheral sympathetic activity of hypophysectomized, adrenalectomized and medullectomized rats

Székács Dániel , Bodnár Ibolya , Nagy György M , Fekete Márton IK

Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), is a recently identified endogenous prolactin (PRL) releasing factor. Salsolinol (SALS) seems to be a selective and potent stimulator of PRL secretion both in vivo and in vitro. 1-Methyl dihydroisoquinoline (1MeDIQ) is an antagonist of salsolinol induced prolactin release and causes increase in plasma norepinephrine (NE) level. SALS decreased the peripheral tissue dopamine (DA) level dose depende...

ea0049ep1046 | Pituitary - Clinical | ECE2017

Heterogeneity of the patient pathway for adult growth hormone deficiency: Perspectives from a CEE Endocrinologists expert panel

Shimon Ilan , Badiu Corin , Bossowski Artur , Doknic Mirjana , Dzivite-Krisane Iveta , Hana Vaclav , Kollerova Jana , Natchev Natchev Emil , Pfeifer Marija , SzŨcs Nikolette , Hey-Hadavi Juliana , Gomez Roy

Introduction: Effective identification, diagnosis and management of growth hormone (GH) deficiency in adults are crucial for treating endocrinologists to provide the best in patient care. As such, it is important that we share our experiences to understand challenges and obstacles to enhance the patient journey. The objective of this project was to start identifying these challenges and obstacles.Methods and findings: In November 2016, an expert panel of...