Endocrine Abstracts

Background: The differential diagnosis between central diabetes insipidus and primary polydipsia is challenging. To date, the most reliable approaches are copeptin measurement after hypertonic saline infusion or arginine, which is a known growth hormone secretagogue but has recently been shown also to stimulate the neurohypophysis. Similar to arginine, glucagon is also known to stimulate growth hormone release, but its effect on the neurohypophysis and in the differential diag...

Introduction: The syndrome of inappropriate antidiuresis (SIADH) is the most common cause of hypoosmolality. Ectopic AVP hypersecretion has long been considered as the primaryn mechanism of SIADH. But different types of osmoregulatory defect in AVP release have been described in this disorder. A comprehensive characterization of these different forms of SIADH in a large cohort of patients may provide important new insights into the still incompletely understood pathophysiology...

Objectives: Graves’ disease (GD) is characterized by variable disease severity at diagnosis and variable disease activity during follow-up. Antithyroid drugs (ATD) such as carbimazole (CMZ), methimazole or propylthiouracil are the first-line treatment. Current guidelines recommend a range of ATD starting dose according to GD severity, followed by dose titration until euthyroidism is reached and a maintenance dose for a specific patient is established. As thyroid hormones ...

Introduction: Persistent endogenous hyperinsulinemic hypoglycemia in neonates (congenital hyperinsulinism; CHI) is usually due to monogenetic gene variants affecting the insulin secretion. The genetic cause is known in about 50% of patients. We present a new variant within the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH) gene causing CHI in two cousins.Methods: The cases of two patients with CHI are presented with a follow-up of >30 ...

Background: The differential diagnosis of diabetes insipidus is challenging. The most reliable diagnostic approach is hypertonic saline-stimulated copeptin measurements. However, as this test is based on the induction of hypernatremia, it is associated with adverse effects and needs close sodium monitoring. We hypothesized that arginine-stimulated copeptin measurements provide an alternative, simple and safe diagnostic test for diabetes insipidus.Methods...