Searchable abstracts of presentations at key conferences in endocrinology

ea0081p150 | Pituitary and Neuroendocrinology | ECE2022

Glucagon-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a double-blind randomized placebo-controlled study

Atila Cihan , Gaisl Odile , Vogt Deborah , Werlen Laura , Szinnai Gabor , Christ-Crain Mirjam

Background: The differential diagnosis between central diabetes insipidus and primary polydipsia is challenging. To date, the most reliable approaches are copeptin measurement after hypertonic saline infusion or arginine, which is a known growth hormone secretagogue but has recently been shown also to stimulate the neurohypophysis. Similar to arginine, glucagon is also known to stimulate growth hormone release, but its effect on the neurohypophysis and in the differential diag...

ea0032p702 | Neuroendocrinology | ECE2013

Copeptin for subtype differentiation of abnormal vasopressin release in SIADH: reclassification and characterization of a novel subtype

Fenske Wiebke , Horning Anna , Simet Jessica , Christ-Crain Mirjam , Szinnai Gabor , Rutishauser Jonas , Stork Stefan , Allolio Bruno

Introduction: The syndrome of inappropriate antidiuresis (SIADH) is the most common cause of hypoosmolality. Ectopic AVP hypersecretion has long been considered as the primaryn mechanism of SIADH. But different types of osmoregulatory defect in AVP release have been described in this disorder. A comprehensive characterization of these different forms of SIADH in a large cohort of patients may provide important new insights into the still incompletely understood pathophysiology...

ea0092ps2-15-08 | Hyperthyroidism | ETA2023

Extended pharmacometrics computer model utilizes heart rate to monitor thyroid function in adults with graves’ disease under carbimazole monotherapy

Steffens Britta , Koch Gilbert , Pfister Marc , Zuger Noemi , Bachmann Freya , Schropp Johannes , Johannes Betz Matthias , Szinnai Gabor

Objectives: GravesÂ’ disease (GD) is characterized by variable disease severity at diagnosis and variable disease activity during follow-up. Antithyroid drugs (ATD) such as carbimazole (CMZ), methimazole or propylthiouracil are the first-line treatment. Current guidelines recommend a range of ATD starting dose according to GD severity, followed by dose titration until euthyroidism is reached and a maintenance dose for a specific patient is established. As thyroid hormones ...

ea0070aep253 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Congenital hyperinsulinemic hypoglycemia: A case report

Widmer Andrea , Zumsteg Urs , Szinnai Gabor , Filges Isabel , Meier Stephanie , Marie Carmen De Geyter Julie , Antwi Kwadwo , Nuoffer Jean-Marc , Wild Damian , Christ Emanuel

Introduction: Persistent endogenous hyperinsulinemic hypoglycemia in neonates (congenital hyperinsulinism; CHI) is usually due to monogenetic gene variants affecting the insulin secretion. The genetic cause is known in about 50% of patients. We present a new variant within the short-chain L-3-hydroxyacyl-CoA dehydrogenase (HADH) gene causing CHI in two cousins.Methods: The cases of two patients with CHI are presented with a follow-up of >30 ...

ea0063oc13.1 | Anterior and Posterior pituitary 2 | ECE2019

Arginine-stimulated copeptin measurements - a new test for diabetes insipidus

Winzeler Bettina , Nigro-Cesana Nicole , Refardt Julie , Vogt Deborah R , Imber Cornelia , Morin Benedict , Popovic Milica , Steinmetz Michelle , Sailer Clara , Szinnai Gabor , Chifu Irina , Fassnacht Martin , Christ-Crain Mirjam

Background: The differential diagnosis of diabetes insipidus is challenging. The most reliable diagnostic approach is hypertonic saline-stimulated copeptin measurements. However, as this test is based on the induction of hypernatremia, it is associated with adverse effects and needs close sodium monitoring. We hypothesized that arginine-stimulated copeptin measurements provide an alternative, simple and safe diagnostic test for diabetes insipidus.Methods...