Searchable abstracts of presentations at key conferences in endocrinology

ea0020s23.3 | Adrenocortical tumours – pathogenesis and management | ECE2009

Prognostic factors and adjuvant mitotane therapy for ACC

Terzolo Massimo

Adrenocortical carcinoma (ACC) is a rare tumour characterized by a dismal prognosis. The most important predictor of outcome is the possibility to attain a complete resection and prognosis is extremely poor when complete surgical removal of ACC is not feasible. Most patients have resectable disease at presentation; however, fully half of the patients who have undergone complete removal of the tumour are destined to relapse. The high recurrence rate of ACC has prompted many inv...

ea0041oc13.1 | Pituitary Clinical | ECE2016

Acromegaly is associated with increased cancer risk: a nationwide survey in Italy on behalf of the Italian study group of acromegaly

Reimondo Giuseppe , Terzolo Massimo , Berchialla Paola , Malchiodi Elena , Arosio Maura

Introduction: That acromegaly may cause cancer remains an unsolved issue. Aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in a nationwide multicenter cohort study in Italy on acromegalic patients who have been treated in the somatostatin-receptor ligands era.Methods and design: We have evaluated the prevalence of neoplasia from a series of 1512 patients who were proactively followed in 24 terti...

ea0070aep17 | Adrenal and Cardiovascular Endocrinology | ECE2020

A double-blind, randomized, placebo-controlled phase 3 study to assess the efficacy and safety of relacorilant, a selective glucocorticoid receptor modulator, in patients with hypercortisolism due to cortisol-secreting adrenal adenoma(s)/hyperplasia

Chiodini Iacopo , Grauer Andreas , Moraitis Andreas , Terzolo Massimo

Relacorilant is a highly selective glucocorticoid receptor modulator that antagonizes the effects of excess cortisol while showing no significant affinity for the mineralocorticoid and progesterone receptors. In a Phase 2 study in patients with endogenous hypercortisolism, relacorilant demonstrated improvements in glycemic and hypertension control with no treatment-related hypokalemia or antiprogesterone effects. An international, multicenter, Phase 3 clinical trial, using ran...

ea0041oc7.4 | Cardiovascular endocrinology | ECE2016

Cortisol autonomy is associated with increased risk of cardiovascular events and mortality in patients with adrenal incidentalomas: beneficial effects of a selective use of adrenalectomy

Reimondo Giuseppe , Mbachu Elena , Pellegrino Micaela , Pia Anna , Pepe Emanuele , Borretta Giorgio , Terzolo Massimo

Introduction: Cortisol autonomy may be frequently demonstrated in patients with adrenal incidentaloma and this has been associated to increased cardiovascular (CV) risk. However, only few data are available on CV events and related mortality in such patients. Aims of the study were: 1) to stratify CV events and mortality by the degree of cortisol secretion; 2) to evaluate the effect of adrenalectomy on CV events and mortality.Methods and Design: Data of ...

ea0037gp.02.05 | Adrenal (1) | ECE2015

Comparison between PET–CT and CT in the diagnosis of recurrence of adrenocortical carcinoma

Massaglia Chiara , Ardito Arianna , Zaggia Barbara , Basile Vittoria , Pelosi Ettore , Arena Vincenzo , Penna Daniele , Terzolo Massimo

Adrenocortical carcinoma (ACC) is a rare tumour characterised by a high rate of recurrence following radical surgery. Surgery of recurrent ACC may increase survival; thus, it is mandatory a timely and accurate detection of recurrence, either to increase the chance of radical extirpation or to avoid unnecessary surgery. This study investigated the role of PET–CT in the diagnosis of recurrence of ACC during follow-up of disease-free patients and analyzed whether this tool m...

ea0032p15 | Adrenal cortex | ECE2013

In vivo and in vitro evidence supporting SSTR/mTOR pathway targeting in adrenocortical cancer

Germano Antonina , Rapa Ida , Duregon Eleonora , Votta Arianna , Ardito Arianna , Volante Marco , Papotti Mauro , Terzolo Massimo

Objective: In vitro data suggest that somatostatin receptors (SSTR) and mTOR pathways might represent reasonable targets for novel therapies, since are involved in growth of adrenocortical carcinoma (ACC). However, in vitro analysis of combination treatments, targeting both mTOR and SSTR as compared to mitotane, and detailed tissue typing mTOR/SSTR pathway are poorly explored in ACC.Methods: This study was designed to characterize the t...

ea0073oc11.4 | Oral Communications 11: Adrenal and Cardiovascular Endocrinoloyg | ECE2021

The management of post-operative recurrences in patients with adrenocortical carcinoma (ACC): The experience of San Luigi Hospital

Calabrese Anna , Puglisi Soraya , Basile Vittoria , Perotti Paola , Berchialla Paola , Pia Anna , Reimondo Giuseppe , Terzolo Massimo

BackgroundThe management of post-operative recurrences of ACC remains controversial, although the current guidelines recommend a surgical approach whenever feasible with radical intent.AimThe aim of our study was to evaluate retrospectively the management of recurrences in patients with ACC. We collected data of 106 patients with ACC followed at the San Luigi Hospital for the management of recurrence. Median ...

ea0063p26 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

How do sex and BMI affect glucocorticoid treatment in adrenal insufficiency?

Puglisi Soraya , Tabaro Isabella , Cannavo Salvatore , Borretta Giorgio , Pellegrino Micaela , Chiappo Francesca , Pia Anna , Terzolo Massimo , Reimondo Giuseppe

Background and objective: Optimization of glucocorticoid (GC) replacement therapy in adrenal insufficiency (AI) is crucial to avoid consequences of under- or overtreatment. Dosing of GC replacement is mainly based on clinical grounds; however, the impact of patient’s characteristics on daily GC requirement is poorly evaluated. The aim of the study is to assess the influence of sex (M/F) and BMI on dosing GC in patients with AI of different etiology....

ea0038p411 | Steroids | SFEBES2015

The effect of adrenalectomy on cardiovascular morbidity in adrenal tumor patients with subclinical Cushing’s syndrome: systematic review and meta-analysis

Bancos Irina , Alahdab Fares , Crowley Rachel , Chortis Vasileios , Erickson Dana , Natt Neena , Terzolo Massimo , Arlt Wiebke , Murad Mohammad

Introduction: Patients with subclinical Cushing’s syndrome (SCS) present with increased cardiovascular morbidity and mortality, however, the beneficial effect of adrenalectomy on cardiovascular risk factors is uncertain.Objective: Systematic meta-analysis to determine the effect of adrenalectomy vs conservative follow-up on cardiovascular risk factors in patients with adrenal tumors and SCS.Methods: We searched 6 databases thr...

ea0032p516 | Endocrine tumours and neoplasia | ECE2013

Comparison of two mitotane starting dose regimens in patients with advanced adrenocortical carcinoma

Kerkhofs Thomas , Baudin Eric , Terzolo Massimo , Allolio Bruno , Chadarevian Rita , Leboulleux Sophie , Mantero Franco , Haak Harm , Fassnacht Martin

Introduction: Current medical treatment of adrenocortical carcinoma (ACC) is based on mitotane alone or in combination with cytotoxic chemotherapy. However, very little is known about the pharmacokinetic properties of mitotane and dosing schedules are based on clinical experience only. The aim of this study was to investigate the relationship between mitotane dose and plasma concentration comparing two pre-defined treatment regimens. Secondary objectives were to evaluate safet...